IL-8RB Antibody (5E8): sc-32780
- IL-8RB Antibody (5E8) is a mouse monoclonal IgG1 κ, cited in 4 publications, provided at 200 µg/ml
- raised against mouse B cell lymphoma L1.2 transfectants expressing IL-8RB of human origin
- recommended for detection of IL-R8B of human origin by WB, IP and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- See IL-8RB (E-2): sc-7304 for IL-8RB antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for IL-8RB Antibody (5E8) for WB applications. These reagents are now offered in bundles with IL-8RB Antibody (5E8) (see ordering information below).
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IL-8RB Antibody (5E8) is a mouse monoclonal IgG1 antibody that detects IL-8RB in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and flow cytometry (FCM). IL-8RB, a member of the seven transmembrane domain rhodopsin superfamily of receptors, plays a crucial role in mediating inflammatory responses by binding to interleukin-8 (IL-8) and other chemokines. IL-8RB is predominantly expressed on neutrophils, with lower levels found on monocytes and certain myeloid cell lines, making anti-IL-8RB antibody (5E8) essential for studying recruitment and activation of these immune cells during inflammation. IL-8RB′s location on the cell surface enables initiation of intracellular signaling cascades upon ligand binding, which leads to various cellular responses, including chemotaxis and degranulation. IL-8RB exhibits high-affinity binding to IL-8, which is vital for function in inflammatory processes, while also interacting with other proteins such as MGSA, thereby amplifying inflammatory response. IL-8RB monoclonal antibody (5E8) serves as an invaluable tool for researchers studying mechanisms of inflammation and chemokine receptor roles in immune responses.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
IL-8RB Antibody (5E8) References:
- Variants of the IL8 and IL8RB genes and risk for gastric cardia adenocarcinoma and esophageal squamous cell carcinoma. | Savage, SA., et al. 2004. Cancer Epidemiol Biomarkers Prev. 13: 2251-7. PMID: 15598788
- Polymorphisms in interleukin 8 and its receptors (IL8, IL8RA and IL8RB) and association of common IL8 receptor variants with peripheral blood eosinophil counts. | Cheong, HS., et al. 2006. J Hum Genet. 51: 781-787. PMID: 16897191
- IL-8, IL-8RA (CXCR1) and IL-8RB (CXCR2) expression in pilomatricoma. | Cianga, CM., et al. 2016. Rom J Morphol Embryol. 57: 59-64. PMID: 27151689
- Bioinformatics approach reveals the key role of C‑X‑C motif chemokine receptor 2 in endometriosis development. | Tan, A., et al. 2018. Mol Med Rep. 18: 2841-2849. PMID: 30015967
- Effect of interleukin-8 receptor B (IL8RB) rs1126579 C>T variation on the risk to cancer. | Zhu, L., et al. 2021. Bioengineered. 12: 3367-3384. PMID: 34238119
- C-X-C motif chemokine ligand 1 and its receptor C-X-C motif chemokine receptor 2 in trigeminal ganglion contribute to nerve injury-induced orofacial mechanical allodynia. | Yang, J., et al. 2022. J Oral Rehabil. 49: 195-206. PMID: 34714950
- Association between IL8RB C1208T mutation and risk of cancer: A pooled analysis based on 5299 cases and 6899 controls. | Sun, HY., et al. 2022. Medicine (Baltimore). 101: e28986. PMID: 35212311
- Protective effect of esculentoside A against myocardial infarction via targeting C-X-C motif chemokine receptor 2. | Gao, M., et al. 2024. Biomed Pharmacother. 174: 116529. PMID: 38569275
- The C-X-C Motif Chemokine Ligand 5, Which Exerts an Antioxidant Role by Inducing HO-1 Expression, Is C-X-C Motif Chemokine Receptor 2-Dependent in Human Prostate Stroma and Cancer Cells. | Chang, KS., et al. 2024. Antioxidants (Basel). 13: PMID: 39765818
- Promoter analysis of the human interleukin-8 receptor genes, IL-8RA and IL-8RB. | Sprenger, H., et al. 1995. Immunobiology. 193: 334-40. PMID: 8530163
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IL-8RB Antibody (5E8) | sc-32780 | 200 µg/ml | $322.00 | |||
IL-8RB Antibody (5E8): m-IgG Fc BP-HRP Bundle | sc-536747 | 200 µg Ab; 10 µg BP | $361.00 | |||
IL-8RB Antibody (5E8): m-IgGκ BP-HRP Bundle | sc-533909 | 200 µg Ab; 40 µg BP | $361.00 | |||
IL-8RB Antibody (5E8): m-IgG1 BP-HRP Bundle | sc-544793 | 200 µg Ab; 20 µg BP | $361.00 | |||
IL-8RB Antibody (5E8) FITC | sc-32780 FITC | 200 µg/ml | $336.00 | |||
IL-8RB Antibody (5E8) PE | sc-32780 PE | 200 µg/ml | $349.00 |