IL-8 Antibody (5D8): sc-101499

IL-8 Antibody (5D8) is a mouse monoclonal IgG1 antibody that detects interleukin-8 (IL-8) in human samples through enzyme-linked immunosorbent assay (ELISA). IL-8 is a crucial chemokine that plays a significant role in the immune response by acting as a chemoattractant for neutrophils, thereby facilitating their migration to sites of inflammation. This function is particularly important in the context of chronic inflammatory diseases, such as inflammatory bowel disease and atherosclerosis, where IL-8 levels are often elevated. IL-8 is initially synthesized as a 99 amino acid precursor, which is then cleaved to produce a biologically active 72 amino acid form. IL-8 exists in both monomeric and dimeric forms, with dimerization serving as a negative regulator of IL-8 receptor function, which includes IL-8RA and IL-8RB receptors that share a high degree of sequence identity and are integral to the signaling pathways of various chemokines. The ability of IL-8 to modulate neutrophil activity and interactions with specific receptors underscore IL-8′s importance in both normal immune function and the pathogenesis of inflammatory diseases. Anti-IL-8 antibody (5D8) is an essential tool for researchers studying these processes and the underlying mechanisms of inflammation.

The preferred IL-8 antibody is IL-8 Antibody (C-11): sc-376750.