IL-3/IL-5/GM-CSFRβ Antibody (B-9): sc-376583

IL-3/IL-5/GM-CSFRβ Antibody (B-9) is a mouse monoclonal IgG2b antibody that detects IL-3/IL-5/GM-CSFRβ in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IL-3/IL-5/GM-CSFRβ plays a crucial role in hematopoiesis by serving as a common β subunit for the receptors of interleukins 3, 5, and granulocyte-macrophage colony-stimulating factor, facilitating high-affinity binding of their respective α subunits. IL-3/IL-5/GM-CSFRβ is primarily located on the surface of hematopoietic cells, where IL-3/IL-5/GM-CSFRβ is essential for mediating cell signaling pathways that promote cell proliferation, differentiation, and survival in response to these cytokines. The interaction of IL-3/IL-5/GM-CSFRβ with its ligands is vital for the regulation of immune responses and the maintenance of blood cell homeostasis, making IL-3/IL-5/GM-CSFRβ a significant target for therapeutic interventions in various hematological disorders. Anti-IL-3/IL-5/GM-CSFRβ antibody (B-9) is an invaluable tool for researchers studying these critical signaling pathways and their implications in health and disease.

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IL-3/IL-5/GM-CSFRβ Antibody (B-9) References:

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3. Characterization of the first nonmammalian T2 cytokine gene cluster: the cluster contains functional single-copy genes for IL-3, IL-4, IL-13, and GM-CSF, a gene for IL-5 that appears to be a pseudogene, and a gene encoding another cytokinelike transcript, KK34.  |  Avery, S., et al. 2004. J Interferon Cytokine Res. 24: 600-10. PMID: 15626157
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The preferred IL-3/IL-5/GM-CSFRβ antibody is IL-3/IL-5/GM-CSFRβ Antibody (1C1): sc-21765.