IL-2Rγ Antibody (A-10): sc-271060
- IL-2Rγ Antibody (A-10) is a mouse monoclonal IgG2a κ IL-2Rγ antibody, cited in 2 publications, provided at 200 µg/ml
- raised against a peptide mapping at the C-terminus of IL-2RΓ of human origin
- IL-2R gamma Antibody (A-10) is recommended for detection of IL-2Rγ of human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-IL-2R gamma Antibody (A-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for IL-2Rγ Antibody (A-10) for WB and IHC(P) applications. These reagents are now offered in bundles with IL-2Rγ Antibody (A-10) (see ordering information below).
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SEE ALSO...
IL-2Rγ Antibody (A-10) is a mouse monoclonal IgG2a kappa light chain antibody that detects IL-2R gamma protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). IL-2Rγ (A-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The IL-2 receptor is a crucial multicomponent complex composed of three subunits: alpha, beta, and gamma, which are essential for high-affinity binding of interleukin-2 (IL-2). The gamma chain, also known as γc, plays a pivotal role in signaling pathways that lead to T cell proliferation and activation. Notably, γc chain is not only a component of the IL-2 receptor but also serves as a common subunit for other cytokine receptors, including IL-4 and IL-7, enhancing their ligand binding capabilities. This functional versatility underscores the importance of IL-2R gamma in immune responses, as γc facilitates communication between cytokines and their receptors, ultimately influencing T cell development and function. Anti-IL-2Rγ antibody (A-10) effectively detects this crucial protein, making IL-2Rγ (A-10) monoclonal antibody an invaluable tool for researchers studying immune signaling pathways and T cell biology.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
IL-2Rγ Antibody (A-10) References:
- A novel monoclonal antibody against murine IL-2 receptor beta-chain. Characterization of receptor expression in normal lymphoid cells and EL-4 cells. | Tanaka, T., et al. 1991. J Immunol. 147: 2222-8. PMID: 1918958
- The murine interleukin-4 receptor: molecular cloning and characterization of secreted and membrane bound forms. | Mosley, B., et al. 1989. Cell. 59: 335-48. PMID: 2805066
- Expression and function of the gamma c subunit of the IL-2, IL-4, and IL-7 receptors. Distinct interaction of gamma c in the IL-4 receptor. | He, YW., et al. 1995. J Immunol. 154: 1596-605. PMID: 7530740
- Biochemical identity and characterization of the mouse interleukin-2 receptor beta and gamma c subunits. | Malek, TR., et al. 1995. J Interferon Cytokine Res. 15: 447-54. PMID: 7648447
- Sharing of the interleukin-2 (IL-2) receptor gamma chain between receptors for IL-2 and IL-4. | Kondo, M., et al. 1993. Science. 262: 1874-7. PMID: 8266076
- Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor. | Russell, SM., et al. 1993. Science. 262: 1880-3. PMID: 8266078
- Characterization of cDNAs encoding the murine interleukin 2 receptor (IL-2R) gamma chain: chromosomal mapping and tissue specificity of IL-2R gamma chain expression. | Cao, X., et al. 1993. Proc Natl Acad Sci U S A. 90: 8464-8. PMID: 8378320
- The IL-2/IL-2 receptor system: a current overview. | Taniguchi, T. and Minami, Y. 1993. Cell. 73: 5-8. PMID: 8462103
- The IL-2 receptor complex: its structure, function, and target genes. | Minami, Y., et al. 1993. Annu Rev Immunol. 11: 245-68. PMID: 8476561
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IL-2Rγ Antibody (A-10) | sc-271060 | 200 µg/ml | $322.00 | |||
IL-2Rγ Antibody (A-10): m-IgG Fc BP-HRP Bundle | sc-529109 | 200 µg Ab; 10 µg BP | $361.00 | |||
IL-2Rγ Antibody (A-10): m-IgGκ BP-HRP Bundle | sc-521834 | 200 µg Ab, 40 µg BP | $361.00 | |||
IL-2Rγ Antibody (A-10): m-IgG2a BP-HRP Bundle | sc-547263 | 200 µg Ab; 10 µg BP | $361.00 | |||
IL-2Rγ Antibody (A-10) AC | sc-271060 AC | 500 µg/ml, 25% agarose | $424.00 | |||
IL-2Rγ Antibody (A-10) HRP | sc-271060 HRP | 200 µg/ml | $322.00 | |||
IL-2Rγ Antibody (A-10) FITC | sc-271060 FITC | 200 µg/ml | $336.00 | |||
IL-2Rγ Antibody (A-10) PE | sc-271060 PE | 200 µg/ml | $349.00 | |||
IL-2Rγ Antibody (A-10) Alexa Fluor® 488 | sc-271060 AF488 | 200 µg/ml | $364.00 | |||
IL-2Rγ Antibody (A-10) Alexa Fluor® 546 | sc-271060 AF546 | 200 µg/ml | $364.00 | |||
IL-2Rγ Antibody (A-10) Alexa Fluor® 594 | sc-271060 AF594 | 200 µg/ml | $364.00 | |||
IL-2Rγ Antibody (A-10) Alexa Fluor® 647 | sc-271060 AF647 | 200 µg/ml | $364.00 | |||
IL-2Rγ Antibody (A-10) Alexa Fluor® 680 | sc-271060 AF680 | 200 µg/ml | $364.00 | |||
IL-2Rγ Antibody (A-10) Alexa Fluor® 790 | sc-271060 AF790 | 200 µg/ml | $364.00 | |||
IL-2Rγ (A-10) Neutralizing Peptide | sc-271060 P | 100 µg/0.5 ml | $69.00 |