IL-2Rβ Antibody (TM-β1): sc-19583

IL-2Rβ Antibody (TM-β1) is a rat monoclonal IgG2b antibody that detects IL-2Rβ in mouse samples through applications such as immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). IL-2Rβ, also known as the interleukin-2 receptor beta chain, plays a crucial role in the immune response by forming part of the high-affinity receptor complex for interleukin-2 (IL-2), a key cytokine involved in T cell proliferation and differentiation. The presence of IL-2Rβ is essential for the activation of signaling pathways that promote T cell growth and survival, making IL-2Rβ a vital component in the regulation of immune responses. Notably, IL-2Rβ interacts with the common gamma chain (γc) and the alpha chain (IL-2Rα), which together enhance the receptor′s affinity for IL-2, thereby amplifying the signaling cascade that leads to T cell activation. Understanding the function and interactions of IL-2Rβ is important for developing therapeutic strategies targeting immune-related diseases, including autoimmune disorders and cancers. IL-2Rβ monoclonal antibody (TM-β1) is an invaluable tool for researchers studying these pathways and their implications in health and disease.

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IL-2Rβ Antibody (TM-β1) References:

1. Biochemical analysis of interleukin-2 receptor beta chain phosphorylation by p56(lck).  |  Delespine-Carmagnat, M., et al. 1999. FEBS Lett. 447: 241-6. PMID: 10214954
2. CIS associates with the interleukin-2 receptor beta chain and inhibits interleukin-2-dependent signaling.  |  Aman, MJ., et al. 1999. J Biol Chem. 274: 30266-72. PMID: 10514520
3. Signal transduction by interleukin 2 receptor beta chain: importance of the structural integrity as revealed by site-directed mutagenesis and generation of chimeric receptors.  |  Mori, H., et al. 1991. Int Immunol. 3: 149-56. PMID: 2025615
4. Characterization of the interleukin 2 receptor beta chain using three distinct monoclonal antibodies.  |  Tsudo, M., et al. 1989. Proc Natl Acad Sci U S A. 86: 1982-6. PMID: 2467293
5. PP2A enables IL-2 signaling by preserving IL-2Rβ chain expression during Treg development.  |  Sharabi, A., et al. 2019. JCI Insight. 5: PMID: 30912768
6. A human orthogonal IL-2 and IL-2Rβ system enhances CAR T cell expansion and antitumor activity in a murine model of leukemia.  |  Zhang, Q., et al. 2021. Sci Transl Med. 13: eabg6986. PMID: 34936380
7. Prevention of acute GVHD using an orthogonal IL-2/IL-2Rβ system to selectively expand regulatory T cells in vivo.  |  Ramos, TL., et al. 2023. Blood. 141: 1337-1352. PMID: 36564052
8. Signaling through the interleukin 2 receptor beta chain activates a STAT-5-like DNA-binding activity.  |  Gaffen, SL., et al. 1995. Proc Natl Acad Sci U S A. 92: 7192-6. PMID: 7543676
9. The chimeric receptor between interleukin-2 receptor beta chain and interleukin-4 receptor transduces interleukin-2 signal.  |  Izuhara, K., et al. 1993. Biochem Biophys Res Commun. 190: 992-1000. PMID: 7679903
10. Distinct tyrosine residues within the interleukin-2 receptor beta chain drive signal transduction specificity, redundancy, and diversity.  |  Gaffen, SL., et al. 1996. J Biol Chem. 271: 21381-90. PMID: 8702919

The preferred IL-2Rβ antibody is IL-2Rβ Antibody (C-2): sc-166427.