IL-2Rβ Activators
The class of IL-2Rβ activators comprises a diverse range of chemicals that intricately modulate immune signaling pathways to achieve selective activation of IL-2Rβ. Betacarotene, an indirect activator, stimulates IL-2Rβ through retinoic acid signaling, emphasizing the role of vitamin A metabolites in immune modulation. Forskolin indirectly activates IL-2Rβ by elevating cAMP levels, leading to protein kinase A (PKA)-mediated modulation of IL-2Rβ expression. 1,25-Dihydroxyvitamin D3 activates IL-2Rβ by enhancing the transcriptional activity of vitamin D receptor (VDR), illustrating the involvement of vitamin D signaling in IL-2Rβ activation. Retinoic acid directly activates IL-2Rβ by forming a transcriptional complex with retinoic acid receptors (RARs), providing a specific mechanism for retinoic acid-induced immune activation.
Resveratrol activates IL-2Rβ indirectly through SIRT1 modulation, showcasing the role of epigenetic regulators in IL-2Rβ activation. Curcumin activates IL-2Rβ indirectly by inhibiting the NF-κB pathway, alleviating negative regulators of IL-2Rβ. Quercetin activates IL-2Rβ indirectly by modulating the MAPK pathway, providing insights into the regulation of IL-2Rβ expression by MAPK signaling. Genistein activates IL-2Rβ indirectly by modulating the JAK/STAT pathway, highlighting the intricate regulation of IL-2Rβ by signaling cascades involved in immune responses. EGCG activates IL-2Rβ indirectly by inhibiting the NF-κB pathway, providing another example of NF-κB-mediated modulation of IL-2Rβ expression. Diallyl disulfide activates IL-2Rβ indirectly through NF-κB inhibition, emphasizing its role in promoting IL-2Rβ expression. α-Lipoic acid activates IL-2Rβ indirectly by modulating the NF-κB pathway, showcasing the diverse set of activators targeting NF-κB-mediated regulation of IL-2Rβ. Berberine activates IL-2Rβ indirectly through MAPK inhibition, revealing the interconnected signaling events influencing IL-2Rβ expression and function. These IL-2Rβ activators collectively provide a nuanced understanding of the molecular mechanisms orchestrating immune activation through selective modulation of IL-2Rβ-dependent pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
β-Carotene | 7235-40-7 | sc-202485 sc-202485A sc-202485B sc-202485C | 1 g 25 g 50 g 5 kg | $80.00 $351.00 $621.00 $12791.00 | 5 | |
β-Carotene activates IL-2Rβ indirectly by influencing the retinoic acid signaling pathway. As a precursor to retinoic acid, betacarotene enhances the transcriptional activity of retinoic acid receptors (RARs), leading to increased expression of IL-2Rβ. The activation of IL-2Rβ by betacarotene is mediated through the retinoic acid-dependent modulation of gene expression, highlighting the role of retinoic acid signaling in IL-2Rβ activation. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates IL-2Rβ indirectly by stimulating adenylate cyclase and increasing intracellular cyclic AMP (cAMP) levels. Elevated cAMP levels activate protein kinase A (PKA), which in turn modulates the activity of transcription factors involved in IL-2Rβ expression. Forskolin's indirect activation of IL-2Rβ through the cAMP/PKA pathway illustrates the interconnected signaling events influencing IL-2Rβ expression and function. | ||||||
1α,25-Dihydroxyvitamin D3 | 32222-06-3 | sc-202877B sc-202877A sc-202877C sc-202877D sc-202877 | 50 µg 1 mg 5 mg 10 mg 100 µg | $220.00 $645.00 $1000.00 $1500.00 $440.00 | 32 | |
1,25-Dihydroxyvitamin D3 activates IL-2Rβ by binding to the vitamin D receptor (VDR) and enhancing its transcriptional activity. The activated VDR complex regulates the expression of genes involved in IL-2Rβ signaling, leading to increased IL-2Rβ expression. The activation of IL-2Rβ by 1,25-dihydroxyvitamin D3 emphasizes the role of vitamin D signaling in modulating immune responses through IL-2Rβ-dependent pathways. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid directly activates IL-2Rβ by binding to retinoic acid receptors (RARs) and forming a transcriptional complex. This complex enhances the transcriptional activity of RARs, leading to increased expression of IL-2Rβ. The direct activation of IL-2Rβ by retinoic acid highlights the specific role of retinoic acid signaling in promoting IL-2Rβ expression and function. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates IL-2Rβ indirectly by modulating the Sirtuin-1 (SIRT1) pathway. Resveratrol activates SIRT1, which influences the acetylation status of histones associated with IL-2Rβ gene expression. The indirect activation of IL-2Rβ by resveratrol through the SIRT1 pathway underscores the intricate epigenetic regulation involved in IL-2Rβ expression and function. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin activates IL-2Rβ indirectly by modulating the nuclear factor-kappa B (NF-κB) signaling pathway. Curcumin inhibits NF-κB activation, leading to decreased expression of NF-κB-dependent suppressors of cytokine signaling (SOCS), which negatively regulate IL-2Rβ. The indirect activation of IL-2Rβ by curcumin through NF-κB inhibition highlights its role in alleviating negative regulators and promoting IL-2Rβ expression. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin activates IL-2Rβ indirectly by modulating the mitogen-activated protein kinase (MAPK) pathway. Quercetin inhibits MAPK signaling, leading to decreased expression of MAPK-dependent negative regulators of IL-2Rβ. The indirect activation of IL-2Rβ by quercetin through MAPK inhibition emphasizes the role of MAPK signaling in regulating IL-2Rβ expression and immune responses. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein activates IL-2Rβ indirectly by modulating the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway. Genistein inhibits JAK activity, leading to decreased expression of JAK/STAT-dependent negative regulators of IL-2Rβ. The indirect activation of IL-2Rβ by genistein through JAK/STAT inhibition underscores the intricate regulation of IL-2Rβ expression by signaling cascades involved in immune responses. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG activates IL-2Rβ indirectly by modulating the nuclear factor-kappa B (NF-κB) pathway. EGCG inhibits NF-κB activation, leading to decreased expression of NF-κB-dependent negative regulators of IL-2Rβ. The indirect activation of IL-2Rβ by EGCG through NF-κB inhibition emphasizes the role of NF-κB signaling in regulating IL-2Rβ expression and immune responses. | ||||||
Allyl disulfide | 2179-57-9 | sc-252359 | 25 g | $80.00 | ||
Allyl disulfide activates IL-2Rβ indirectly by modulating the nuclear factor-kappa B (NF-κB) pathway. Diallyl disulfide inhibits NF-κB activation, leading to decreased expression of NF-κB-dependent suppressors of cytokine signaling (SOCS), which negatively regulate IL-2Rβ. The indirect activation of IL-2Rβ by diallyl disulfide through NF-κB inhibition highlights its role in alleviating negative regulators and promoting IL-2Rβ expression. | ||||||