IL-2Rβ Antibody (G-1): sc-393092

IL-2Rβ Antibody (G-1) is a mouse monoclonal IgG2a antibody that detects IL-2Rβ in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IL-2Rβ, a critical component of the interleukin-2 receptor complex, plays a vital role in the immune response by mediating the effects of IL-2, a key cytokine involved in T cell proliferation and differentiation. The IL-2 receptor is composed of three subunits: α, β, and γ, with the β chain being essential for the receptor′s high-affinity binding to IL-2 and for initiating downstream signaling pathways that promote T cell growth and survival. Notably, IL-2Rβ interacts with the common γ chain (γc), which is shared among several cytokine receptors, including IL-4R and IL-7R, thereby enhancing the receptor′s overall functionality. Proper functioning of IL-2Rβ is crucial for maintaining immune homeostasis, and dysregulation of this receptor can lead to various immunological disorders, making anti-IL-2Rβ antibody (G-1) an invaluable tool for researchers studying T cell biology and related diseases.

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IL-2Rβ Antibody (G-1) References:

1. Identification of three adjacent amino acids of interleukin-2 receptor beta chain which control the affinity and the specificity of the interaction with interleukin-2.  |  Imler, JL., et al. 1992. EMBO J. 11: 2047-53. PMID: 1600937
2. Flow cytometric analysis of expression of interleukin-2 receptor beta chain (p70-75) on various leukemic cells.  |  Hoshino, S., et al. 1990. Blood. 76: 767-74. PMID: 2383656
3. The human interleukin 2 receptor beta chain (p70). Direct identification, partial purification, and patterns of expression on peripheral blood mononuclear cells.  |  Sharon, M., et al. 1988. J Exp Med. 167: 1265-70. PMID: 2832509
4. TransCon IL-2 β/γ: a novel long-acting prodrug with sustained release of an IL-2Rβ/γ-selective IL-2 variant with improved pharmacokinetics and potent activation of cytotoxic immune cells for the treatment of cancer.  |  Rosen, DB., et al. 2022. J Immunother Cancer. 10: PMID: 35817480
5. A Chimeric IL-7Rα/IL-2Rβ Receptor Promotes the Differentiation of T Cell Progenitors into B Cells and Type 2 Innate Lymphoid Cells.  |  Shimba, A., et al. 2024. J Immunol. 213: 952-964. PMID: 39140896
6. SH2-dependent association of phosphatidylinositol 3'-kinase 85-kDa regulatory subunit with the interleukin-2 receptor beta chain.  |  Truitt, KE., et al. 1994. J Biol Chem. 269: 5937-43. PMID: 7509794
7. The cytoplasmic domain of the interleukin-2 receptor beta chain contains both unique and functionally redundant signal transduction elements.  |  Goldsmith, MA., et al. 1994. J Biol Chem. 269: 14698-704. PMID: 8182077
8. The serine-rich cytoplasmic domain of the interleukin-2 receptor beta chain is essential for interleukin-2-dependent tyrosine protein kinase and phosphatidylinositol-3-kinase activation.  |  Merida, I., et al. 1993. J Biol Chem. 268: 6765-70. PMID: 8384218
9. Staphylococcal enterotoxin B up-regulates interleukin-2 receptor beta chain expression on tonsillar B cells.  |  Franz, A., et al. 1993. Eur J Immunol. 23: 2696-9. PMID: 8405068
10. Delineation of the regions of interleukin-2 (IL-2) receptor beta chain important for association of Jak1 and Jak3. Jak1-independent functional recruitment of Jak3 to Il-2Rbeta.  |  Zhu, MH., et al. 1998. J Biol Chem. 273: 10719-25. PMID: 9553136

The preferred IL-2Rβ antibody is IL-2Rβ Antibody (C-2): sc-166427.