IL-2 Antibody (G-6): sc-393947

IL-2 Antibody (G-6) is a mouse monoclonal IgG2b antibody that detects interleukin-2 (IL-2) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IL-2 plays a crucial role in the immune response by promoting the proliferation and differentiation of T cells, particularly activated T helper and cytotoxic T cells, which are essential for effective immune defense against pathogens. IL-2 is primarily secreted by activated helper T cells, and IL-2 signaling is vital for the growth and survival of B cells, thereby linking the adaptive immune response. Notably, IL-2 is involved in three distinct signal transduction pathways that facilitate biological effects: the c-Fos/c-Jun induction pathway, the c-Myc induction pathway, and the Rapamycin-sensitive pathway, all of which contribute to the regulation of anti-apoptotic proteins like Bcl-2. Furthermore, the transcription factor NFAT is integral to the transcriptional regulation of IL-2, and NFAT activity has been associated with age-related declines in IL-2 expression, highlighting the importance of IL-2 in maintaining immune function throughout life. With an ability to facilitate critical immune processes, IL-2 is a key target for therapeutic interventions in various immune-related conditions, making anti-IL-2 antibody (G-6) an invaluable tool for researchers studying immune responses and related pathways.

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IL-2 Antibody (G-6) References:

1. Cytochalasans and PMA induce IL-2 receptors on CD8+ lymphocytes.  |  Grove, DS., et al. 1992. Exp Cell Res. 202: 303-9. PMID: 1397084
2. Inhibition by anti-HLA class I mAb of IL-2 and IL-2 receptor synthesis in lymphocytes stimulated with PHA-P.  |  De Felice, M., et al. 1990. Cell Immunol. 126: 420-7. PMID: 2311126
3. Immune dysfunctions and activation of natural killer cells in human IL-2 and IL-2/IL-2 receptor L-chain transgenic mice.  |  Ishida, Y., et al. 1989. Cold Spring Harb Symp Quant Biol. 54 Pt 2: 695-704. PMID: 2640624
4. IL-2 induces pulmonary edema and vasoconstriction independent of circulating lymphocytes.  |  Ferro, TJ., et al. 1989. J Immunol. 142: 1916-21. PMID: 2784141
5. IL-2 regulation of tyrosine kinase activity is mediated through the p70-75 beta-subunit of the IL-2 receptor.  |  Ferris, DK., et al. 1989. J Immunol. 143: 870-6. PMID: 2787350
6. A hybrid protein between IFN-gamma and IL-2.  |  Seno, M., et al. 1986. FEBS Lett. 199: 187-92. PMID: 3009218
7. Soluble plasma IL-2 receptors and malaria.  |  Riley, EM., et al. 1993. Clin Exp Immunol. 91: 495-9. PMID: 8443969
8. Regulation of resting and IL-2-activated human cytotoxic lymphocytes by exogenous nucleotides: role of IL-2 and ecto-ATPases.  |  Bajpai, A. and Brahmi, Z. 1993. Cell Immunol. 148: 130-43. PMID: 8495483
9. Morphine inhibits transcriptional activation of IL-2 in mouse thymocytes.  |  Roy, S., et al. 1997. Cell Immunol. 179: 1-9. PMID: 9259765
10. Stimulation of IL-2 production and CD2R expression by splenopentin analogs.  |  Biswas, S., et al. 1997. Int J Immunopharmacol. 19: 341-5. PMID: 9467753

The preferred IL-2 antibody is IL-2 Antibody (I2t-C7): sc-57285.