IL-2 Antibody (C2-1-hIL2): sc-32295

IL-2 Antibody (C2-1-hIL2) is a mouse monoclonal IgG2a antibody that detects interleukin-2 (IL-2) in human samples through applications such as western blotting (WB) and immunoprecipitation (IP). IL-2 is a crucial cytokine primarily secreted by activated helper T cells, playing a vital role in the immune response by promoting the proliferation of T cells and B cells. Anti-IL-2 antibody (C2-1-hIL2) is essential for studying growth and differentiation of T cells, particularly in the context of immune activation, as IL-2 helps sustain immune response against pathogens. The IL-2 signaling pathway involves several key interactions, including the activation of transcription factors such as NFAT, which is critical for IL-2 gene expression. IL-2 interacts with specific receptors on T cells, leading to the activation of downstream signaling cascades that enhance cell survival and proliferation. Understanding the function and regulation of IL-2 is important for developing therapeutic strategies in immunology, particularly in conditions such as cancer and autoimmune diseases, where modulation of the immune response can have significant clinical implications. IL-2 monoclonal antibody (C2-1-hIL2) serves as an invaluable tool for researchers studying these pathways and their effects on immune cell behavior.

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IL-2 Antibody (C2-1-hIL2) References:

1. IL-2: the first effective immunotherapy for human cancer.  |  Rosenberg, SA. 2014. J Immunol. 192: 5451-8. PMID: 24907378
2. Role of IL-2 in cancer immunotherapy.  |  Jiang, T., et al. 2016. Oncoimmunology. 5: e1163462. PMID: 27471638
3. IL-2 and Beyond in Cancer Immunotherapy.  |  Wrangle, JM., et al. 2018. J Interferon Cytokine Res. 38: 45-68. PMID: 29443657
4. Prospects of IL-2 in Cancer Immunotherapy.  |  Choudhry, H., et al. 2018. Biomed Res Int. 2018: 9056173. PMID: 29854806
5. Engineering IL-2 for immunotherapy of autoimmunity and cancer.  |  Hernandez, R., et al. 2022. Nat Rev Immunol. 22: 614-628. PMID: 35217787
6. An IL-2 Protein Therapeutic for Cancer that Gains Function on the Spot.  |  Silva, DA. 2022. Cancer Immunol Res. 10: 544. PMID: 35436336
7. The soluble IL-2 receptor α/CD25 as a modulator of IL-2 function.  |  Lokau, J., et al. 2024. Immunology. 171: 377-387. PMID: 38037265
8. Optimising IL-2 for Cancer Immunotherapy.  |  Sprent, J. and Boyman, O. 2024. Immune Netw. 24: e5. PMID: 38455463
9. The role of IL-2 cytokine family in asthma.  |  Goleij, P., et al. 2024. Cytokine. 180: 156638. PMID: 38761716
10. Clinical applications of IL-2.  |  Sznol, M. and Parkinson, DR. 1994. Oncology (Williston Park). 8: 61-7; discussion 67, 71, 74-5. PMID: 7521197

The preferred IL-2 antibody is IL-2 Antibody (I2t-C7): sc-57285.