IL-1 beta/IL1B Antibody (F-5): sc-515598

IL-1β Antibody (F-5) is a mouse monoclonal IgG2a kappa light chain antibody that detects IL-1β in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IL-1β Antibody (F-5) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. IL-1β is a key pro-inflammatory cytokine that plays a vital role in mediating immune responses and inflammation. IL-1β is primarily produced by activated macrophages and is crucial for the activation of T and B lymphocytes, as well as natural killer (NK) cells. IL-1β is secreted in response to various stimuli, including infection and tissue injury, and IL-1β dysregulation has been implicated in numerous inflammatory diseases, such as rheumatoid arthritis and inflammatory bowel disease. Notably, IL-1β undergoes post-translational modifications, including cleavage by caspase-1, which is essential for activation. This processing not only regulates IL-1β bioactivity but also influences IL-1β interaction with other proteins in the inflammatory signaling pathways, highlighting IL-1β importance in both normal immune function and pathological conditions.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IL-1 beta/IL1B Antibody (F-5) has 32 citations in a variety of scientific publications.

Primary antibodies like Anti-IL-1 beta/IL1B Antibody (F-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IL-1 beta/IL1B Antibody (F-5) Specifications

Alternate Product Name: IL1B

Product Clone Name: F-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 238-268

Epitope Target: IL-1β

Epitope Species: rat

Product Reactivity/Detection: IL-1β

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 32 citations in various scientific publications

Available Conjugates/Forms for IL-1 beta/IL1B Antibody (F-5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred IL-1 beta/IL1B antibody is IL-1 beta/IL1B Antibody (B122): sc-12742.