IL-1 beta/IL1B Antibody (11E5): sc-52012

IL-1β Antibody (11E5) is a mouse monoclonal IgG1 antibody that detects IL-1β in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-IL-1β antibody (11E5) is available in a non-conjugated form, allowing for versatile experimental use. IL-1β, a key pro-inflammatory cytokine, plays a crucial role in mediating immune responses and inflammation. IL-1β is primarily produced by activated macrophages and is involved in various physiological processes, including the regulation of T and B lymphocyte activation. Notably, IL-1β is secreted as an inactive precursor, which is then cleaved by caspase-1 to generate the active form, highlighting the importance of post-translational modifications in its function. This activation process is essential for IL-1β′s role in promoting the production of other inflammatory mediators and enhancing the immune response. Dysregulation of IL-1β has been implicated in several inflammatory diseases, including rheumatoid arthritis and inflammatory bowel disease, making IL-1β a significant target for therapeutic intervention.

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IL-1 beta/IL1B Antibody (11E5) References:

1. Targeting IL-1beta in disease; the expanding role of NLRP3 inflammasome.  |  Mitroulis, I., et al. 2010. Eur J Intern Med. 21: 157-63. PMID: 20493414
2. Effects of IL-1β, IL-6 and IL-8 on erythrocytes, platelets and clot viscoelasticity.  |  Bester, J. and Pretorius, E. 2016. Sci Rep. 6: 32188. PMID: 27561337
3. Role of autophagy in IL-1β export and release from cells.  |  Claude-Taupin, A., et al. 2018. Semin Cell Dev Biol. 83: 36-41. PMID: 29580970
4. Melatonin modulates IL-1β-induced extracellular matrix remodeling in human nucleus pulposus cells and attenuates rat intervertebral disc degeneration and inflammation.  |  Zhang, Y., et al. 2019. Aging (Albany NY). 11: 10499-10512. PMID: 31772145
5. IL-1β promotes immunoregulatory responses in human blood basophils.  |  Iype, J., et al. 2021. Allergy. 76: 2017-2029. PMID: 33544413
6. Macrophage/microglia-derived IL-1β induces glioblastoma growth via the STAT3/NF-κB pathway.  |  Kai, K., et al. 2022. Hum Cell. 35: 226-237. PMID: 34591282
7. IL-1β Induces a Proinflammatory Fibroblast Microenvironment that Impairs Lung Progenitors' Function.  |  Ciminieri, C., et al. 2023. Am J Respir Cell Mol Biol. 68: 444-455. PMID: 36608844
8. The mechanisms and functions of IL-1β in intervertebral disc degeneration.  |  Li, H., et al. 2023. Exp Gerontol. 177: 112181. PMID: 37088216
9. Inhibition of the uric acid efflux transporter ABCG2 enhances stimulating effect of soluble uric acid on IL-1β production in murine macrophage-like J774.1 cells.  |  Notsu, T., et al. 2023. Hypertens Res. 46: 2368-2377. PMID: 37592041
10. Baicalin inhibits IL-1β-induced ferroptosis in human osteoarthritis chondrocytes by activating Nrf-2 signaling pathway.  |  Liu, J., et al. 2024. J Orthop Surg Res. 19: 23. PMID: 38166985

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IL-1 beta/IL1B Antibody (11E5) has 162 citations in a variety of scientific publications.

Primary antibodies like Anti-IL-1 beta/IL1B Antibody (11E5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IL-1 beta/IL1B Antibody (11E5) Specifications

Alternate Product Name: IL1B

Product Clone Name: 11E5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: IL-1β

Epitope Species: human

Product Reactivity/Detection: IL-1β

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 162 citations in various scientific publications

Available Conjugates/Forms for IL-1 beta/IL1B Antibody (11E5): N/A

The preferred IL-1 beta/IL1B antibody is IL-1 beta/IL1B Antibody (B122): sc-12742.