IL-17R Antibody (G-9): sc-376374
- IL-17R Antibody (G-9) is a mouse monoclonal IgG1 κ IL-17R antibody, cited in 17 publications, provided at 200 µg/ml
- raised against amino acids 33-200 mapping within an N-terminal extracellular domain of IL-17R of human origin
- IL-17R Antibody (G-9) is recommended for detection of IL-17R of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-IL-17R Antibody (G-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for IL-17R Antibody (G-9) for WB applications. These reagents are now offered in bundles with IL-17R Antibody (G-9) (see ordering information below).
IL-17R Antibody (G-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects IL-17R of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IL-17R (G-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. IL-17R, a type I transmembrane protein consisting of 864 amino acids, plays a crucial role in mediating immune response by binding to interleukin-17 (IL-17). This interaction triggers a cascade of signaling events that lead to immune cell activation and production of pro-inflammatory cytokines, such as IL-6 and IL-8. IL-17R is predominantly expressed in spleen and kidney, highlighting importance in immune regulation and inflammation. Dysregulation of IL-17 signaling has been implicated in various autoimmune diseases, making IL-17R studies essential for understanding and potentially targeting these conditions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
IL-17R Antibody (G-9) References:
- Herpesvirus saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor. | Yao, Z., et al. 2011. J Immunol. 187: 4392-402. PMID: 22013205
- Effect of IL-17 receptor A blockade with brodalumab in inflammatory diseases. | Nirula, A., et al. 2016. Rheumatology (Oxford). 55: ii43-ii55. PMID: 27856660
- IL-17 receptor-based signaling and implications for disease. | Li, X., et al. 2019. Nat Immunol. 20: 1594-1602. PMID: 31745337
- CMTM4 is a subunit of the IL-17 receptor and mediates autoimmune pathology. | Knizkova, D., et al. 2022. Nat Immunol. 23: 1644-1652. PMID: 36271145
- Donor IL-17 receptor A regulates LPS-potentiated acute and chronic murine lung allograft rejection. | Watanabe, T., et al. 2023. JCI Insight. 8: PMID: 37937643
- Cloning of a new cytokine that induces IFN-gamma production by T cells. | Okamura, H., et al. 1995. Nature. 378: 88-91. PMID: 7477296
- Human IL-17: a novel cytokine derived from T cells. | Yao, Z., et al. 1995. J Immunol. 155: 5483-6. PMID: 7499828
- Binding of IL-1 alpha, IL-1 beta, and IL-1 receptor antagonist by soluble IL-1 receptors and levels of soluble IL-1 receptors in synovial fluids. | Arend, WP., et al. 1994. J Immunol. 153: 4766-74. PMID: 7963543
- CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene. | Rouvier, E., et al. 1993. J Immunol. 150: 5445-56. PMID: 8390535
- Cytokine function: a study in biologic diversity. | Cohen, MC. and Cohen, S. 1996. Am J Clin Pathol. 105: 589-98. PMID: 8623768
- Janus kinases in cytokine signalling. | Ihle, JN. 1996. Philos Trans R Soc Lond B Biol Sci. 351: 159-66. PMID: 8650262
- Complete nucleotide sequence of the mouse CTLA8 gene. | Yao, Z., et al. 1996. Gene. 168: 223-5. PMID: 8654948
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IL-17R Antibody (G-9) | sc-376374 | 200 µg/ml | $322.00 | |||
IL-17R Antibody (G-9): m-IgG Fc BP-HRP Bundle | sc-529861 | 200 µg Ab; 10 µg BP | $361.00 | |||
IL-17R Antibody (G-9): m-IgGκ BP-HRP Bundle | sc-522933 | 200 µg Ab, 40 µg BP | $361.00 | |||
IL-17R Antibody (G-9): m-IgG1 BP-HRP Bundle | sc-543730 | 200 µg Ab; 20 µg BP | $361.00 | |||
IL-17R Antibody (G-9) AC | sc-376374 AC | 500 µg/ml, 25% agarose | $424.00 | |||
IL-17R Antibody (G-9) HRP | sc-376374 HRP | 200 µg/ml | $322.00 | |||
IL-17R Antibody (G-9) FITC | sc-376374 FITC | 200 µg/ml | $336.00 | |||
IL-17R Antibody (G-9) PE | sc-376374 PE | 200 µg/ml | $349.00 | |||
IL-17R Antibody (G-9) Alexa Fluor® 488 | sc-376374 AF488 | 200 µg/ml | $364.00 | |||
IL-17R Antibody (G-9) Alexa Fluor® 546 | sc-376374 AF546 | 200 µg/ml | $364.00 | |||
IL-17R Antibody (G-9) Alexa Fluor® 594 | sc-376374 AF594 | 200 µg/ml | $364.00 | |||
IL-17R Antibody (G-9) Alexa Fluor® 647 | sc-376374 AF647 | 200 µg/ml | $364.00 | |||
IL-17R Antibody (G-9) Alexa Fluor® 680 | sc-376374 AF680 | 200 µg/ml | $364.00 | |||
IL-17R Antibody (G-9) Alexa Fluor® 790 | sc-376374 AF790 | 200 µg/ml | $364.00 |