IL-17E Antibody (68C1039): sc-52933

IL-17E Antibody (68C1039) is a mouse monoclonal IgG2b antibody that detects IL-17E in mouse, rat, and human samples through western blotting (WB). Anti-IL-17E antibody (68C1039) is offered in a non-conjugated form, allowing for versatile applications in research. IL-17E, a member of the interleukin-17 family, plays a crucial role in the immune response by acting as a proinflammatory cytokine. IL-17E is primarily secreted by activated T cells and forms a disulfide-linked homodimeric glycoprotein structure, essential for biological activity. IL-17E binds to IL-17 receptor homolog 1 (EV127/IL-17BR), leading to activation of downstream signaling pathways such as NF-kB, which stimulates production of proinflammatory chemokines like IL-8. IL-17E has been implicated in catabolic processes affecting human articular cartilage, highlighting potential roles in inflammatory diseases. IL-17E mRNA expression remains low in various peripheral tissues, suggesting a tightly regulated role in immune responses. IL-17E functions as a unique pleiotropic cytokine that may serve as a significant mediator in both inflammatory and immune pathways, making IL-17E monoclonal antibody (68C1039) a valuable tool for studying these critical biological processes.

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IL-17E Antibody (68C1039) References:

1. IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1.  |  Lee, J., et al. 2001. J Biol Chem. 276: 1660-4. PMID: 11058597
2. IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding.  |  Hymowitz, SG., et al. 2001. EMBO J. 20: 5332-41. PMID: 11574464
3. Cutting edge: IL-17F, a novel cytokine selectively expressed in activated T cells and monocytes, regulates angiogenesis and endothelial cell cytokine production.  |  Starnes, T., et al. 2001. J Immunol. 167: 4137-40. PMID: 11591732
4. Forced expression of murine IL-17E induces growth retardation, jaundice, a Th2-biased response, and multiorgan inflammation in mice.  |  Pan, G., et al. 2001. J Immunol. 167: 6559-67. PMID: 11714825
5. Functional specialization of interleukin-17 family members.  |  Iwakura, Y., et al. 2011. Immunity. 34: 149-62. PMID: 21349428
6. IL-17A and its homologs IL-25/IL-17E recruit the c-RAF/S6 kinase pathway and the generation of pro-oncogenic LMW-E in breast cancer cells.  |  Mombelli, S., et al. 2015. Sci Rep. 5: 11874. PMID: 26154409
7. Targeting the Tumor Microenvironment: The Protumor Effects of IL-17 Related to Cancer Type.  |  Fabre, J., et al. 2016. Int J Mol Sci. 17: PMID: 27589729
8. IL-25 blockade inhibits metastasis in breast cancer.  |  Jiang, Z., et al. 2017. Protein Cell. 8: 191-201. PMID: 27909985
9. Cisplatin inhibits the growth, migration and invasion of cervical cancer cells by down-regulating IL-17E/IL-17RB.  |  Cheng, J., et al. 2017. Int J Clin Exp Pathol. 10: 9341-9351. PMID: 31966806
10. Much More Than IL-17A: Cytokines of the IL-17 Family Between Microbiota and Cancer.  |  Brevi, A., et al. 2020. Front Immunol. 11: 565470. PMID: 33244315
11. New insights into the function of Interleukin-25 in disease pathogenesis.  |  Yuan, Q., et al. 2023. Biomark Res. 11: 36. PMID: 37005677
12. T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines.  |  Fossiez, F., et al. 1996. J Exp Med. 183: 2593-603. PMID: 8676080

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IL-17E Antibody (68C1039) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-IL-17E Antibody (68C1039) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IL-17E Antibody (68C1039) Specifications

Alternate Product Name: IL-17E

Product Clone Name: 68C1039

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b

Amino Acids: 115-132

Epitope Target: IL-17E

Epitope Species: human

Product Reactivity/Detection: IL-17E

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB

Vialing Information: Each vial contains 100 µg IgG_2b in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for IL-17E Antibody (68C1039): N/A