IL-17E Antibody (30479): sc-74175
- IL-17E Antibody (30479) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against full length recombinant IL-17E of human origin
- recommended for detection of IL-17E of mouse, rat and human origin by WB, FCM and ELISA; non cross-reactive with IL-17, IL-17B, C and F
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for IL-17E Antibody (30479). This work is in progress.
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IL-17E Antibody (30479) is a mouse monoclonal IgG1 antibody that detects Interleukin 17E (IL-17E) in mouse, rat, and human samples through applications such as western blotting (WB), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). IL-17E is a proinflammatory cytokine that plays a crucial role in mediating immune responses and inflammation. IL-17E is secreted as a disulfide-linked homodimeric glycoprotein and interacts with IL-17 receptor homolog 1, also referred to as EV127/IL-17BR. IL-17E mRNA expression remains low in various peripheral tissues, yet activation leads to significant biological effects, including NF-kB induction and proinflammatory chemokine stimulation such as IL-8. IL-17E has been shown to exert catabolic effects on human articular cartilage, highlighting potential involvement in inflammatory joint diseases. IL-17E is part of a unique family of cytokines that includes IL-17F, expressed in activated CD4(+) T cells and monocytes, and regulates production of other cytokines, thereby influencing cartilage matrix turnover. Anti-IL-17E antibody (30479) serves as an essential tool for researchers studying complex roles of IL-17E in inflammation and immune regulation.
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IL-17E Antibody (30479) References:
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- An Interleukin-25-Mediated Autoregulatory Circuit in Keratinocytes Plays a Pivotal Role in Psoriatic Skin Inflammation. | Xu, M., et al. 2018. Immunity. 48: 787-798.e4. PMID: 29653697
- Estrogen Receptor Downregulates Expression of PD-1/PD-L1 and Infiltration of CD8+ T Cells by Inhibiting IL-17 Signaling Transduction in Breast Cancer. | Shuai, C., et al. 2020. Front Oncol. 10: 582863. PMID: 33102239
- Comparative studies on mannan and imiquimod induced experimental plaque psoriasis inflammation in inbred mice. | Wu, H., et al. 2023. Clin Exp Immunol. 211: 288-300. PMID: 36645209
- Association between new plasma inflammatory markers and risk of colorectal neoplasms in individuals over 50 years old. | Su, JY., et al. 2023. Carcinogenesis. 44: 824-836. PMID: 37713476
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IL-17E Antibody (30479) | sc-74175 | 100 µg/ml | $316.00 |