IL-13Rα1 Antibody (GM-1C8): sc-101381

IL-13Rα1 Antibody (GM-1C8) is a mouse monoclonal IgG1 antibody that detects Interleukin-13 receptor alpha 1 (IL-13Rα1) in human samples through flow cytometry (FCM) and enzyme-linked immunosorbent assay (ELISA) applications. IL-13Rα1 plays a pivotal role in mediating the effects of the Th2 cytokine Interleukin-13, which is crucial for regulating immune responses, particularly in allergic reactions and asthma. IL-13Rα1 is primarily expressed as a heterodimer with IL-4Rα, facilitating signaling pathways that promote B cell differentiation and immunoglobulin production. IL-13Rα1′s location on the cell surface enables downstream signaling cascades upon binding to IL-13, which can lead to enhanced airway hyper-responsiveness in allergic conditions. In contrast, the decoy receptor IL-13Rα2, which is also present in the system, can inhibit IL-13 signaling, highlighting the delicate balance between these receptors in modulating immune responses. Anti-IL-13Rα1 antibody (GM-1C8) is an essential tool for researchers investigating the complex roles of IL-13 signaling in various pathophysiological contexts, including allergic diseases and cancer.

The preferred IL-13Rα1 antibody is IL-13Rα1 Antibody (D-2): sc-398831.