IL-13R alpha 1 Antibody (GM-1C8): sc-101381

IL-13Rα1 Antibody (GM-1C8) is a mouse monoclonal IgG1 antibody that detects Interleukin-13 receptor alpha 1 (IL-13Rα1) in human samples through flow cytometry (FCM) and enzyme-linked immunosorbent assay (ELISA) applications. IL-13Rα1 plays a pivotal role in mediating the effects of the Th2 cytokine Interleukin-13, which is crucial for regulating immune responses, particularly in allergic reactions and asthma. IL-13Rα1 is primarily expressed as a heterodimer with IL-4Rα, facilitating signaling pathways that promote B cell differentiation and immunoglobulin production. IL-13Rα1′s location on the cell surface enables downstream signaling cascades upon binding to IL-13, which can lead to enhanced airway hyper-responsiveness in allergic conditions. In contrast, the decoy receptor IL-13Rα2, which is also present in the system, can inhibit IL-13 signaling, highlighting the delicate balance between these receptors in modulating immune responses. Anti-IL-13Rα1 antibody (GM-1C8) is an essential tool for researchers investigating the complex roles of IL-13 signaling in various pathophysiological contexts, including allergic diseases and cancer.

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Contains Mercury: All HRP conjugates (including bundle forms) contain thiomersal, a mercury compound. Do not dispose in trash. Dispose as hazardous chemical waste according to local, state and federal regulations.

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IL-13R alpha 1 Antibody (GM-1C8) References:

1. IL-13 receptors and signaling pathways: an evolving web.  |  Hershey, GK. 2003. J Allergy Clin Immunol. 111: 677-90; quiz 691. PMID: 12704343
2. Involvement of IL-4, IL-13 and Their Receptors in Pancreatic Cancer.  |  Shi, J., et al. 2021. Int J Mol Sci. 22: PMID: 33804263
3. Recent advances in understanding the role of IL-4 signaling.  |  Keegan, AD., et al. 2021. Fac Rev. 10: 71. PMID: 34557875
4. IL-4/IL-13 axis as therapeutic targets in allergic rhinitis and asthma.  |  Nur Husna, SM., et al. 2022. PeerJ. 10: e13444. PMID: 35663523
5. Cadherin-26 Amplifies Airway Epithelial IL-4 Receptor Signaling in Asthma.  |  Feng, Y., et al. 2022. Am J Respir Cell Mol Biol. 67: 539-549. PMID: 35930423
6. Epithelial cell-expressed type II IL-4 receptor mediates eosinophilic esophagitis.  |  Avlas, S., et al. 2023. Allergy. 78: 464-476. PMID: 36070083
7. The IL-4/IL-13 signaling axis promotes prostatic fibrosis.  |  D'Arcy, Q., et al. 2022. PLoS One. 17: e0275064. PMID: 36201508
8. Keratinocytes activated by IL-4/IL-13 express IL-2Rγ with consequences on epidermal barrier function.  |  Progneaux, A., et al. 2023. Exp Dermatol. 32: 660-670. PMID: 36645024
9. Tralokinumab Effectively Disrupts the IL-13/IL-13Rα1/IL-4Rα Signaling Complex but Not the IL-13/IL-13Rα2 Complex.  |  Tollenaere, MAX., et al. 2023. JID Innov. 3: 100214. PMID: 37554517
10. IL-4 and IL-13 induce equivalent expression of traditional M2 markers and modulation of reactive oxygen species in human macrophages.  |  Scott, TE., et al. 2023. Sci Rep. 13: 19589. PMID: 37949903

The preferred IL-13Rα1 antibody is IL-13Rα1 Antibody (D-2): sc-398831.