IL-12Rβ1 Antibody (E-6): sc-166805

IL-12Rβ1 Antibody (E-6) is a mouse monoclonal IgG2a antibody that detects IL-12Rβ1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IL-12Rβ1 is a critical component of the interleukin-12 receptor complex, which plays a vital role in mediating the immune response, particularly in the differentiation of T helper 1 (Th1) cells. IL-12Rβ1 on the surface of immune cells allows for IL-12 binding, leading to the activation of signaling pathways that promote interferon-gamma (IFN-γ) production and enhance natural killer (NK) cell cytotoxic activity. This interaction is essential for developing robust immune responses against intracellular pathogens and tumors. Notably, IL-12Rβ1 expression is less restricted compared to IL-12Rβ2, which is crucial for Th1 differentiation. Understanding IL-12Rβ1 expression and function is important, as dysregulation of this pathway can contribute to various autoimmune diseases, including multiple sclerosis and Crohn′s disease, while therapeutic modulation of IL-12 signaling may offer new avenues for treating allergic disorders and asthma. With proven detection capabilities across multiple species and applications, anti-IL-12Rβ1 antibody (E-6) serves as an invaluable tool for researchers investigating immune responses and related pathologies.

The preferred IL-12Rβ1 antibody is IL-12Rβ1 Antibody (A-10): sc-166776.