IL-12B p40 Antibody (G-6): sc-374651

IL-12B p40 Antibody (G-6) is a mouse monoclonal IgG1 antibody that detects IL-12B p40 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IL-12B p40 plays a crucial role in the immune response as a subunit of the heterodimeric cytokine interleukin-12 (IL-12), which is essential for the differentiation of naive CD4(+) T cells into type 1 helper T cells that produce interferon-γ (IFN-γ). This process is vital for the activation of T and natural killer (NK) cells, which are key players in the body′s defense against infections and tumors. Additionally, IL-12B p40 can combine with p19 to form IL-23, another important cytokine that shares some functional properties with IL-12, including the activation of the transcription factor Stat4 and the promotion of IFN-γ production. IL-12B p40′s ability to influence both IL-12 and IL-23 pathways highlights its significance in regulating immune responses, making anti-IL-12B p40 antibody (G-6) an invaluable tool for researchers studying immune system dynamics and related diseases.

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IL-12B p40 Antibody (G-6) References:

1. Linkage disequilibrium of a type 1 diabetes susceptibility locus with a regulatory IL12B allele.  |  Morahan, G., et al. 2001. Nat Genet. 27: 218-21. PMID: 11175794
2. Associations of the IL12B promoter polymorphism in longitudinal data from asthmatic patients 7 to 42 years of age.  |  Khoo, SK., et al. 2004. J Allergy Clin Immunol. 113: 475-81. PMID: 15007350
3. A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes.  |  Cargill, M., et al. 2007. Am J Hum Genet. 80: 273-90. PMID: 17236132
4. An inducible enhancer required for Il12b promoter activity in an insulated chromatin environment.  |  Zhou, L., et al. 2007. Mol Cell Biol. 27: 2698-712. PMID: 17242186
5. IL23R and IL12B SNPs and Haplotypes Strongly Associate with Crohn's Disease Risk in a New Zealand Population.  |  Ferguson, LR., et al. 2010. Gastroenterol Res Pract. 2010: 539461. PMID: 21253534
6. A polymorphism in the coding region of Il12b promotes IL-12p70 and IL-23 heterodimer formation.  |  Zwiers, A., et al. 2011. J Immunol. 186: 3572-80. PMID: 21321105
7. Effect of IL12A and IL12B polymorphisms on the risk of Chlamydia trachomatis-induced tubal factor infertility and disease severity.  |  Ohman, H., et al. 2012. Hum Reprod. 27: 2217-23. PMID: 22581790
8. Detection of Mycobacterium avium subspecies paratuberculosis in patients with Crohn's disease is unrelated to the presence of single nucleotide polymorphisms rs2241880 (ATG16L1) and rs10045431 (IL12B).  |  Dalton, JP., et al. 2014. Med Microbiol Immunol. 203: 195-205. PMID: 24522266
9. Influence of genetic polymorphisms of IL23R, STAT3, IL12B, and STAT4 on the risk of aplastic anemia and the effect of immunosuppressive therapy.  |  Zhao, L., et al. 2018. Ann Hematol. 97: 685-695. PMID: 29330562
10. Autosomal Recessive IL-12p40 Deficiency due to a Mutation in the IL12B Gene: Report of a Brazilian Patient with Lymph Node Mycobacterial Infection.  |  Melo, KM., et al. 2024. Pediatr Allergy Immunol Pulmonol. 37: 33-36. PMID: 38484269

The preferred IL-12B p40 antibody is IL-12B p40 Antibody (F-10): sc-365389.