IKKβ Antibody (62AT216): sc-130152
- IKKβ Antibody (62AT216) is a mouse monoclonal IgG1, cited in 2 publications, provided at 100 µg/ml
- raised against full-length recombinant IKKβ of human origin
- recommended for detection of IKKβ of human origin by WB, IP and ELISA
- See IKKβ (H-4): sc-8014 for IKKβ antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for IKKβ Antibody (62AT216). This work is in progress.
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IKKβ Antibody (62AT216) is a mouse monoclonal IgG1 antibody that detects IKKβ in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). IKKβ, a key component of the IKK complex, plays a crucial role in the activation of the transcription factor NFκB, which is essential for regulating immune responses, inflammation, and cell survival. Located primarily in the cytoplasm, IKKβ interacts with IκB proteins, facilitating their phosphorylation and subsequent degradation, which allows NFκB to translocate to the nucleus and initiate gene expression. IKKβ′s cytoplasmic retention ensures that NFκB remains inactive until appropriate signaling events occur, preventing unwanted activation that could lead to chronic inflammation or autoimmune diseases. The IKK complex, which includes IKKα, IKKβ, and IKKγ (NEMO), is vital for the phosphorylation of IκB proteins, and precise regulation of this process is critical for maintaining cellular homeostasis and responding to external stimuli. Anti-IKKβ antibody (62AT216) is an invaluable tool for researchers studying NFκB signaling pathways and their implications in various diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
IKKβ Antibody (62AT216) References:
- IKKβ regulates endothelial thrombomodulin in a Klf2-dependent manner. | Pathak, R., et al. 2014. J Thromb Haemost. 12: 1533-1544. PMID: 25039491
- IKKβ in intestinal mesenchymal cells promotes initiation of colitis-associated cancer. | Koliaraki, V., et al. 2015. J Exp Med. 212: 2235-51. PMID: 26621453
- Inhibition of IKKβ Reduces Ethanol Consumption in C57BL/6J Mice. | Truitt, JM., et al. 2016. eNeuro. 3: PMID: 27822501
- IKKβ is a β-catenin kinase that regulates mesenchymal stem cell differentiation. | Sui, Y., et al. 2018. JCI Insight. 3: PMID: 29367460
- Intestinal Epithelial Cells Regulate Gut Eotaxin Responses and Severity of Allergy. | Kim, E., et al. 2018. Front Immunol. 9: 1692. PMID: 30123215
- Identification of an IKKβ inhibitor for inhibition of inflammation in vivo and in vitro. | Chen, Q., et al. 2019. Pharmacol Res. 149: 104440. PMID: 31479750
- Inhibition of IKKβ/NF-κB signaling facilitates tendinopathy healing by rejuvenating inflamm-aging induced tendon-derived stem/progenitor cell senescence. | Wang, C., et al. 2022. Mol Ther Nucleic Acids. 27: 562-576. PMID: 35036066
- Phosphatase inhibition by sodium orthovanadate displays anti-inflammatory action by suppressing AKT-IKKβ signaling in RAW264.7 cells. | Kim, HG., et al. 2022. Toxicol Rep. 9: 1883-1893. PMID: 36518371
- The inhibitor of κB kinase β (IKKβ) phosphorylates IκBα twice in a single binding event through a sequential mechanism. | Stephenson, AA., et al. 2023. J Biol Chem. 299: 102796. PMID: 36528060
- Targeting IKKβ Activity to Limit Sterile Inflammation in Acetaminophen-Induced Hepatotoxicity in Mice. | Kim, SH., et al. 2023. Pharmaceutics. 15: PMID: 36840032
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IKKβ Antibody (62AT216) | sc-130152 | 100 µg/ml | $322.00 |