IGFBP3 Antibody (B-5): sc-365936

IGFBP3 Antibody (B-5) is a mouse monoclonal IgG2b kappa light chain antibody raised against amino acids 113-210 of human IGFBP3, detecting both precursor and mature forms of IGFBP3 from mouse, rat, and human origin in applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). IGFBP3, also known as Insulin-like Growth Factor Binding Protein 3, IBP3, or BP-53, is the most abundant IGF-binding protein in circulation and is predominantly secreted into the extracellular space and bloodstream. The extracellular localization of IGFBP3 is crucial because IGFBP3 binds to insulin-like growth factors IGF-I and IGF-II, modulating their bioavailability, extending their half-life, and regulating their interaction with IGF receptors, thereby influencing vital cellular processes like growth, proliferation, and apoptosis. Additionally, IGFBP3 can translocate into the nucleus, where IGFBP3 exerts IGF-independent effects such as regulating gene transcription and inducing apoptosis, which is particularly important in cancer biology and therapy. The ability of IGFBP3 to function both extracellularly and intracellularly highlights IGFBP3′s multifaceted role in cellular physiology and potential as a therapeutic target. Alterations in IGFBP3 expression or function have been associated with various pathological conditions, including growth disorders, diabetes, and cancer, underscoring the importance of studying this protein. anti-IGFBP3 antibody (B-5) is available in both non-conjugated and multiple conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and various Alexa Fluor® conjugates, making anti-IGFBP3 antibody (B-5) a versatile tool for research applications involving IGFBP3 and its role in health and disease.

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IGFBP3 Antibody (B-5) has 10 citations in a variety of scientific publications.

Primary antibodies like Anti-IGFBP3 Antibody (B-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IGFBP3 Antibody (B-5) Specifications

Alternate Product Name: IGFBP3

Product Clone Name: B-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 113-210

Epitope Target: IGFBP3

Epitope Species: human

Product Reactivity/Detection: precursor and mature IGFBP3

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 10 citations in various scientific publications

Available Conjugates/Forms for IGFBP3 Antibody (B-5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred IGFBP3 antibody is IGFBP3 Antibody (E-9): sc-374365.