IGFBP2 Antibody (G-1): sc-365368
- IGFBP2 Antibody (G-1) is a mouse monoclonal IgG2a κ, cited in 4 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 313-328 at the C-terminus of IGFBP2 of human origin
- recommended for detection of precursor and mature IGFBP2 of human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for IGFBP2 Antibody (G-1) for WB applications. These reagents are now offered in bundles with IGFBP2 Antibody (G-1) (see ordering information below).
IGFBP2 Antibody (G-1) is a mouse monoclonal IgG2a antibody that detects Insulin-like growth factor-binding protein 2 (IGFBP2) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IGFBP2 plays a crucial role in the regulation of insulin-like growth factors (IGFs) by acting as a chaperone that escorts IGFs to their target tissues, thereby influencing their bioavailability and activity. IGFBP2 is expressed in various human tissues, including the fetal eye and fetal brain, highlighting its importance during development and in response to physiological changes. Anti-IGFBP2 antibody (G-1) enables reliable detection and quantification of IGFBP2, supporting research into diverse biological functions and potential therapeutic applications, particularly in conditions such as cancer and diabetes where IGF signaling impacts cellular growth, differentiation, and metabolism.
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IGFBP2 Antibody (G-1) References:
- IGFBP2 potentiates nuclear EGFR-STAT3 signaling. | Chua, CY., et al. 2016. Oncogene. 35: 738-47. PMID: 25893308
- An IGFBP2-derived peptide promotes neuroplasticity and rescues deficits in a mouse model of Phelan-McDermid syndrome. | Burgdorf, JS., et al. 2023. Mol Psychiatry. 28: 1101-1111. PMID: 36481930
- Redox-dependent Igfbp2 signaling controls Brca1 DNA damage response to govern neural stem cell fate. | Shahin, WS., et al. 2023. Nat Commun. 14: 444. PMID: 36707536
- FGF1 ameliorates obesity-associated hepatic steatosis by reversing IGFBP2 hypermethylation. | Wang, J., et al. 2023. FASEB J. 37: e22881. PMID: 36934380
- IGFBP2 from a novel copper metabolism-associated biomarker promoted glioma progression and response to immunotherapy. | Luo, Q., et al. 2023. Front Immunol. 14: 1282734. PMID: 37928523
- IGFBP2 drives epithelial-mesenchymal transition in hepatocellular carcinoma via activating the Wnt/β-catenin pathway. | Chen, X., et al. 2023. Infect Agent Cancer. 18: 73. PMID: 37957694
- Increased IGFBP2 Levels by Placenta-Derived Mesenchymal Stem Cells Enhance Glucose Metabolism in a TAA-Injured Rat Model via AMPK Signaling Pathway. | Lee, DH., et al. 2023. Int J Mol Sci. 24: PMID: 38003735
- Age-Related Increases in IGFBP2 Increase Melanoma Cell Invasion and Lipid Synthesis. | Alicea, GM., et al. 2024. Cancer Res Commun. 4: 1908-1918. PMID: 39007351
- Disease-relevant upregulation of P2Y1 receptor in astrocytes enhances neuronal excitability via IGFBP2. | Shigetomi, E., et al. 2024. Nat Commun. 15: 6525. PMID: 39117630
- Mutant PP2A Induces IGFBP2 Secretion to Promote Development of High-Grade Uterine Cancer. | Haanen, TJ., et al. 2025. Cancer Res. 85: 442-461. PMID: 39531506
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IGFBP2 Antibody (G-1) | sc-365368 | 200 µg/ml | $316.00 | |||
IGFBP2 Antibody (G-1): m-IgG Fc BP-HRP Bundle | sc-540332 | 200 µg Ab; 10 µg BP | $354.00 | |||
IGFBP2 Antibody (G-1): m-IgG2a BP-HRP Bundle | sc-546893 | 200 µg Ab; 10 µg BP | $354.00 | |||
IGFBP2 (G-1) Neutralizing Peptide | sc-365368 P | 100 µg/0.5 ml | $68.00 |