IGFBP2 Antibody (C-10): sc-25285

IGFBP2 Antibody (C-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects IGFBP2 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IGFBP2 (C-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Insulin-like growth factor-binding proteins (IGFBPs) are a family of homologous proteins that play a crucial role in regulating bioavailability and activity of insulin-like growth factors (IGFs) within the extracellular environment. IGFBP2 functions as a chaperone, facilitating IGF transport to target tissues, which is essential for proper growth and development. IGFBP2 is expressed in various human tissues, including fetal eye and fetal brain, highlighting IGFBP2′s importance during developmental processes. IGFBP2 exhibits biological activities independent of IGFs, further underscoring IGFBP2′s multifaceted role in cellular signaling and regulation. IGFBP2′s diverse functions and interactions with other IGFBPs, such as IGFBP3 and IGFBP5, contribute to a complex network of growth factor regulation, making anti-IGFBP2 antibody (C-10) a valuable tool for research in developmental biology and disease states.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

IGFBP2 Antibody (C-10) References:

1. Spatial Transcriptomic Analysis of Ovarian Cancer Precursors Reveals Reactivation of IGFBP2 during Pathogenesis.  |  Wang, Y., et al. 2022. Cancer Res. 82: 4528-4541. PMID: 36206311
2. Loss of IGFBP2 mediates alveolar type 2 cell senescence and promotes lung fibrosis.  |  Chin, C., et al. 2023. Cell Rep Med. 4: 100945. PMID: 36787736
3. IGFBP2 expressing midlobular hepatocytes preferentially contribute to liver homeostasis and regeneration.  |  Lin, YH., et al. 2023. Cell Stem Cell. 30: 665-676.e4. PMID: 37146585
4. IGFBP2 secretion by mammary adipocytes limits breast cancer invasion.  |  Conway, JRW., et al. 2023. Sci Adv. 9: eadg1840. PMID: 37436978
5. Cancer-associated fibroblast-associated gene IGFBP2 promotes glioma progression through induction of M2 macrophage polarization.  |  Zhang, X., et al. 2024. Am J Physiol Cell Physiol. 326: C252-C268. PMID: 37982173
6. Insulin-like growth factor binding proteins as glucoregulators.  |  Baxter, RC. 1995. Metabolism. 44: 12-7. PMID: 7476305
7. Structure and localization of the IGFBP-1 gene and its expression during liver regeneration.  |  Lee, J., et al. 1994. Hepatology. 19: 656-65. PMID: 7509771
8. Insulin-like growth factors.  |  Schmid, C. 1995. Cell Biol Int. 19: 445-57. PMID: 7640658
9. The IGF system in metabolism regulation.  |  Binoux, M. 1995. Diabete Metab. 21: 330-7. PMID: 8586149
10. Differential expression of IGFBPs by normal and hypertrophic scar fibroblasts.  |  Hathaway, CL., et al. 1996. J Surg Res. 60: 156-62. PMID: 8592408
11. Insulin-like growth factor-binding proteins (IGFBPs) and their regulatory dynamics.  |  Kelley, KM., et al. 1996. Int J Biochem Cell Biol. 28: 619-37. PMID: 8673727
12. Synthesis and characterization of insulin-like growth factor-binding protein (IGFBP)-7. Recombinant human mac25 protein specifically binds IGF-I and -II.  |  Oh, Y., et al. 1996. J Biol Chem. 271: 30322-5. PMID: 8939990

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IGFBP2 Antibody (C-10) has 10 citations in a variety of scientific publications.

Primary antibodies like Anti-IGFBP2 Antibody (C-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IGFBP2 Antibody (C-10) Specifications

Alternate Product Name: IGFBP2

Product Clone Name: C-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-75

Epitope Target: IGFBP2

Epitope Species: human

Product Reactivity/Detection: IGFBP2

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 10 citations in various scientific publications

Available Conjugates/Forms for IGFBP2 Antibody (C-10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin