IGF-1 Receptor α/IGF1R Antibody (26-3): sc-80987
- IGF-1 Receptor α/IGF1R Antibody (26-3) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against transfected 3T3 cells overexpressing IGF-IRα of human origin
- recommended for detection of IGF-IRα of human origin by IP; non cross-reactive with IGR-IRα of rat origin and insulin-Rα of human origin
- See IGF-1 Receptor α/IGF1R (G-5): sc-271606 for IGF-1 Receptor α/IGF1R antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for IGF-1 Receptor α/IGF1R Antibody (26-3). These reagents are now offered in bundles with IGF-1 Receptor α/IGF1R Antibody (26-3) (see ordering information below).
IGF-IRα Antibody (26-3) is a mouse monoclonal IgG1 antibody that detects insulin-like growth factor-I receptor (IGF-IR) in human samples through immunoprecipitation (IP). IGF-IR plays a crucial role in cellular signaling pathways that regulate growth and survival, making IGF-IR (26-3) antibody a significant tool in cancer research and therapeutic development. This receptor tyrosine kinase resides on the cell membrane, where IGF-IR acts as a transducer of growth signals initiated by insulin-like growth factor-I (IGF-I). IGF-I binding to IGF-IR triggers a cascade of intracellular events, including Ras and ERK pathway activation, which drive cell proliferation and differentiation. IGF-IR′s membrane location enables rapid signal transduction and interaction with downstream signaling molecules, such as insulin receptor substrates (IRS), which further propagate growth signals. The human IGF-IR gene, located on chromosome 15q26.3, encodes a precursor protein that forms α and β subunits essential for functional activity. Anti-IGF-IR antibody (26-3) enables researchers to study IGF-IR signaling dynamics and implications in various biological processes and diseases.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IGF-1 Receptor α/IGF1R Antibody (26-3) | sc-80987 | 200 µg/ml | $322.00 | |||
IGF-1 Receptor α/IGF1R Antibody (26-3): m-IgG Fc BP-HRP Bundle | sc-539580 | 200 µg Ab; 10 µg BP | $361.00 | |||
IGF-1 Receptor α/IGF1R Antibody (26-3): m-IgG1 BP-HRP Bundle | sc-541572 | 200 µg Ab; 20 µg BP | $361.00 |