IGF-1 Receptor α/IGF1R Antibody (G-5): sc-271606

IGF-IRα Antibody (G-5) is a mouse monoclonal IgG1 kappa light chain antibody that detects IGF-IR alpha in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). IGF-IRα (G-5) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The insulin-like growth factor-I receptor (IGF-IR) plays a crucial role as a receptor tyrosine kinase, influencing vital cellular processes such as growth, survival, and differentiation. Located on the cell membrane, IGF-IR is activated by insulin-like growth factor-I (IGF-I), which leads to receptor dimerization and autophosphorylation, triggering downstream signaling pathways that include the Ras/ERK and PI3K/Akt pathways. These pathways regulate gene expression and cellular responses to growth signals, making IGF-IR significant in both normal physiology and cancer pathogenesis. The human IGF-IR gene is located on chromosome 15q26.3 and encodes a precursor protein that is cleaved into α and β subunits, highlighting the complexity of structure and function. IGF-IR′s ability to mediate critical growth signals makes anti-IGF-IRα antibody (G-5) valuable for research and clinical applications, particularly in cancer treatment studies.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IGF-1 Receptor α/IGF1R Antibody (G-5) has 12 citations in a variety of scientific publications.

Primary antibodies like Anti-IGF-1 Receptor α/IGF1R Antibody (G-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IGF-1 Receptor α/IGF1R Antibody (G-5) Specifications

Alternate Product Name: IGF1R

Product Clone Name: G-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 123-200

Epitope Target: IGF-IRα

Epitope Species: human

Product Reactivity/Detection: IGF-IRα

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 12 citations in various scientific publications

Available Conjugates/Forms for IGF-1 Receptor α/IGF1R Antibody (G-5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred IGF-1 Receptor α/IGF1R antibody is IGF-1 Receptor α/IGF1R Antibody (2C8): sc-463.