IGF-1 Receptor α/IGF1R Antibody (16-13): sc-80985

IGF-IRα Antibody (16-13) is a mouse monoclonal IgG2b antibody that detects insulin-like growth factor-I receptor (IGF-IR) in human samples through immunoprecipitation (IP). IGF-IR plays a crucial role in cellular signaling pathways that regulate growth, survival, and differentiation, making IGF-IR a significant player in various physiological processes and disease states, including cancer. IGF-IR is primarily located on the cell membrane, where IGF-IR acts as a transmembrane molecular scaffold that facilitates the binding of insulin-like growth factor-I (IGF-I). This interaction triggers a cascade of intracellular signaling events, including the activation of the Ras and ERK pathways, which ultimately influence gene expression and cellular behavior. IGF-IR′s membrane-bound position allows for rapid response to extracellular signals, thereby modulating critical cellular functions. The human IGF-IR gene, located on chromosome 15q26.3, encodes a precursor protein that is cleaved into α and β subunits, further emphasizing the complexity and regulatory mechanisms involved in IGF-IR function. Through interactions with various adaptor proteins, IGF-IR initiates downstream signaling essential for maintaining cellular homeostasis and responding to growth factors, making anti-IGF-IRα antibody (16-13) a valuable tool for researchers studying these vital processes.

The preferred IGF-1 Receptor α/IGF1R antibody is IGF-1 Receptor α/IGF1R Antibody (2C8): sc-463.