IGF-II Antibody (D-10): sc-518128
- IGF-II Antibody (D-10) is a mouse monoclonal IgM κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 55-74 of IGF-II of mouse origin
- recommended for detection of IGF-II of mouse and rat origin by WB, IP, IF and ELISA
- Anti-IGF-II Antibody (D-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgGκ BP-HRP is the preferred secondary detection reagent for IGF-II Antibody (D-10) for WB applications. This reagent is now offered in a bundle with IGF-II Antibody (D-10) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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SEE ALSO...
IGF-II Antibody (D-10) is a mouse monoclonal IgM antibody that detects IGF-II in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IGF-II (D-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. IGF-II plays a crucial role in fetal development, acting as a growth factor primarily expressed in the placenta and regulated by placental lactogen. IGF-II is essential for proper growth and development during prenatal stages, influencing cell proliferation and differentiation. IGF-II is involved in the regulation of metabolic processes and has been linked to various gene variants associated with overfeeding-induced metabolic changes. The human IGF-II gene is located on chromosome 11p15.5 and encodes a 180 amino acid precursor protein that undergoes post-translational modifications, including glycosylation, which are vital for stability and biological activity. Understanding the function and regulation of IGF-II is important for elucidating its role in growth disorders and metabolic diseases, making anti-IGF-II antibody (D-10) a valuable tool for researchers studying these critical biological processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
IGF-II Antibody (D-10) References:
- IGF-I and IGF-II in relation to colorectal cancer. | Manousos, O., et al. 1999. Int J Cancer. 83: 15-7. PMID: 10449601
- Placental anionic and cationic amino acid transporter expression in growth hormone overexpressing and null IGF-II or null IGF-I receptor mice. | Matthews, JC., et al. 1999. Placenta. 20: 639-50. PMID: 10527818
- IGF-I, IGF-II, and IGF-receptor-1 transcript and IGF-II protein expression in myostatin knockout mice tissues. | Kocamis, H., et al. 2002. Muscle Nerve. 26: 55-63. PMID: 12115949
- Interactions of pro-cathepsin D and IGF-II on the mannose-6-phosphate/IGF-II receptor. | Vignon, F. and Rochefort, H. 1992. Breast Cancer Res Treat. 22: 47-57. PMID: 1421424
- The effects of IGF-I and IGF-II on cell growth and differentiation in the central nervous system. | Lauterio, TJ. 1992. Adv Exp Med Biol. 321: 31-6. PMID: 1449082
- Interactions of IGF-II with the IGF2R/cation-independent mannose-6-phosphate receptor mechanism and biological outcomes. | Brown, J., et al. 2009. Vitam Horm. 80: 699-719. PMID: 19251056
- Biology and significance of signalling pathways activated by IGF-II. | Harris, LK. and Westwood, M. 2012. Growth Factors. 30: 1-12. PMID: 22136428
- Maternal and fetal IGF-I and IGF-II levels, fetal growth, and gestational diabetes. | Luo, ZC., et al. 2012. J Clin Endocrinol Metab. 97: 1720-8. PMID: 22419731
- Radioimmunoassay of serum IGF-I and IGF-II in patients with chronic liver diseases and hepatocellular carcinoma with or without hypoglycemia. | Wu, JC., et al. 1988. J Lab Clin Med. 112: 589-94. PMID: 2460570
- Alteration of oncogenic IGF-II gene methylation status associates with hepatocyte malignant transformation. | Tai, BJ., et al. 2019. Hepatobiliary Pancreat Dis Int. 18: 158-163. PMID: 30692043
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IGF-II Antibody (D-10) | sc-518128 | 200 µg/ml | $316.00 | |||
IGF-II Antibody (D-10): m-IgGκ BP-HRP Bundle | sc-525392 | 200 µg Ab, 40 µg BP | $354.00 | |||
IGF-II Antibody (D-10) AC | sc-518128 AC | 500 µg/ml, 25% agarose | $416.00 | |||
IGF-II Antibody (D-10) HRP | sc-518128 HRP | 200 µg/ml | $316.00 | |||
IGF-II Antibody (D-10) FITC | sc-518128 FITC | 200 µg/ml | $330.00 | |||
IGF-II Antibody (D-10) PE | sc-518128 PE | 200 µg/ml | $343.00 | |||
IGF-II Antibody (D-10) Alexa Fluor® 488 | sc-518128 AF488 | 200 µg/ml | $357.00 | |||
IGF-II Antibody (D-10) Alexa Fluor® 546 | sc-518128 AF546 | 200 µg/ml | $357.00 | |||
IGF-II Antibody (D-10) Alexa Fluor® 594 | sc-518128 AF594 | 200 µg/ml | $357.00 | |||
IGF-II Antibody (D-10) Alexa Fluor® 647 | sc-518128 AF647 | 200 µg/ml | $357.00 | |||
IGF-II Antibody (D-10) Alexa Fluor® 680 | sc-518128 AF680 | 200 µg/ml | $357.00 | |||
IGF-II Antibody (D-10) Alexa Fluor® 790 | sc-518128 AF790 | 200 µg/ml | $357.00 |