IgD chain C Antibody (C-5): sc-393519
- IgD chain C Antibody (C-5) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 284-350 mapping near the C-terminus of IgD of human origin
- Anti-IgD chain C Antibody (C-5) is recommended for detection of IgD of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-IgD chain C Antibody (C-5) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for IgD chain C Antibody (C-5) for WB applications. These reagents are now offered in bundles with IgD chain C Antibody (C-5) (see ordering information below).
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IgD chain C Antibody (C-5) is a mouse monoclonal IgG1 kappa light chain antibody that detects IgD chain C protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IgD chain C (C-5) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. IgD chain C protein, an allelic product of the human IGHD gene, plays a crucial role in the adaptive immune system, primarily expressed as a monomer by activated B cells. IgD chain C protein consists of three immunoglobulin-like domains and is located on chromosome 14 within the human heavy chain locus, specifically positioned on the 3′ side of the IgM chain C region. The structural arrangement of IgD chain C protein is significant as it influences the alternative splicing mechanisms that determine whether B cells express IgD or IgM, which are vital for the immune response. Notably, IgD chain C protein has been linked to the regulation of B cell activation and may impact bone resorption during infectious events, highlighting its importance in immune responses.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
IgD chain C Antibody (C-5) References:
- T cell receptor (TCR) alpha/delta locus enhancer identity and position are critical for the assembly of TCR delta and alpha variable region genes. | Bassing, CH., et al. 2003. Proc Natl Acad Sci U S A. 100: 2598-603. PMID: 12604775
- Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. | Chen, R., et al. 2009. J Proteome Res. 8: 651-61. PMID: 19159218
- B Cell IgD Deletion Prevents Alveolar Bone Loss Following Murine Oral Infection. | Baker, PJ., et al. 2009. Interdiscip Perspect Infect Dis. 2009: 864359. PMID: 19859584
- Molecular footprints of a germinal center derivation of human IgM+(IgD+)CD27+ B cells and the dynamics of memory B cell generation. | Seifert, M. and Küppers, R. 2009. J Exp Med. 206: 2659-69. PMID: 19917772
- Prognostic relevance of in vitro response to cell stimulation via surface IgD in binet stage a CLL. | Morabito, F., et al. 2010. Br J Haematol. 149: 160-3. PMID: 19995391
- The cellular mechanism by which complementary Id+ and anti-Id antibodies communicate: T cells integrated into idiotypic regulation. | Jacobsen, JT., et al. 2010. Immunol Cell Biol. 88: 515-22. PMID: 20066000
- Molecular analysis of IgD-positive human germinal centres. | Müller, C., et al. 2010. Int Immunol. 22: 289-98. PMID: 20139173
- Complete amino acid sequence of the Fc region of a human delta chain. | Shinoda, T., et al. 1981. Proc Natl Acad Sci U S A. 78: 785-9. PMID: 6785754
- Primary structure of the Fc region of human immunoglobulin D: implications for evolutionary origin and biological function. | Lin, LC. and Putnam, FW. 1981. Proc Natl Acad Sci U S A. 78: 504-8. PMID: 6787589
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IgD chain C Antibody (C-5) | sc-393519 | 200 µg/ml | $316.00 | |||
IgD chain C Antibody (C-5): m-IgG Fc BP-HRP Bundle | sc-530479 | 200 µg Ab; 10 µg BP | $354.00 | |||
IgD chain C Antibody (C-5): m-IgGκ BP-HRP Bundle | sc-523977 | 200 µg Ab, 40 µg BP | $354.00 | |||
IgD chain C Antibody (C-5): m-IgG1 BP-HRP Bundle | sc-544075 | 200 µg Ab; 20 µg BP | $354.00 | |||
IgD chain C Antibody (C-5) AC | sc-393519 AC | 500 µg/ml, 25% agarose | $416.00 | |||
IgD chain C Antibody (C-5) HRP | sc-393519 HRP | 200 µg/ml | $316.00 | |||
IgD chain C Antibody (C-5) FITC | sc-393519 FITC | 200 µg/ml | $330.00 | |||
IgD chain C Antibody (C-5) PE | sc-393519 PE | 200 µg/ml | $343.00 | |||
IgD chain C Antibody (C-5) Alexa Fluor® 488 | sc-393519 AF488 | 200 µg/ml | $357.00 | |||
IgD chain C Antibody (C-5) Alexa Fluor® 546 | sc-393519 AF546 | 200 µg/ml | $357.00 | |||
IgD chain C Antibody (C-5) Alexa Fluor® 594 | sc-393519 AF594 | 200 µg/ml | $357.00 | |||
IgD chain C Antibody (C-5) Alexa Fluor® 647 | sc-393519 AF647 | 200 µg/ml | $357.00 | |||
IgD chain C Antibody (C-5) Alexa Fluor® 680 | sc-393519 AF680 | 200 µg/ml | $357.00 | |||
IgD chain C Antibody (C-5) Alexa Fluor® 790 | sc-393519 AF790 | 200 µg/ml | $357.00 |