iGb3 Antibody (H-7): sc-514782

iGb3 Antibody (H-7) is a mouse monoclonal IgM kappa antibody that detects iGb3 protein of mouse and rat origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-iGb3 antibody (H-7) is available in a non-conjugated form, specifically designed for iGb3 applications. iGb3, also known as isogloboside 3 or isoglobotrihexosylceramide, is a 370 amino acid protein that plays a crucial role in natural killer T cell development by synthesizing the galactose-alpha(1,3)-galactose group on alpha-galactose. iGb3 is localized in the Golgi apparatus, where iGb3 is involved in glycosylating lipids and requires manganese as a cofactor for enzymatic activity. Proper functioning of iGb3 is essential for immune responses, as iGb3 influences the activation and differentiation of T cells, which are vital for the body′s defense against pathogens. The gene encoding iGb3 is located on human chromosome 1, a region that spans 260 million base pairs and contains over 3,000 genes, many of which are associated with various diseases, including familial adenomatous polyposis and Parkinson′s disease. Using iGb3 monoclonal antibody (H-7) in research can provide valuable insights into iGb3′s role in immune system regulation and disease implications.

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iGb3 Antibody (H-7) References:

1. Two novel polymorphic sequences in the glucocerebrosidase gene region enhance mutational screening and founder effect studies of patients with Gaucher disease.  |  Lau, EK., et al. 1999. Hum Genet. 104: 293-300. PMID: 10369158
2. Exclusion of an extracolonic disease modifier locus on chromosome 1p33-36 in a large Swiss familial adenomatous polyposis kindred.  |  Plasilova, M., et al. 2004. Eur J Hum Genet. 12: 365-71. PMID: 14735163
3. Identification of risk and age-at-onset genes on chromosome 1p in Parkinson disease.  |  Oliveira, SA., et al. 2005. Am J Hum Genet. 77: 252-64. PMID: 15986317
4. Normal development and function of invariant natural killer T cells in mice with isoglobotrihexosylceramide (iGb3) deficiency.  |  Porubsky, S., et al. 2007. Proc Natl Acad Sci U S A. 104: 5977-82. PMID: 17372206
5. The schizophrenia brain exhibits low-level aneuploidy involving chromosome 1.  |  Yurov, YB., et al. 2008. Schizophr Res. 98: 139-47. PMID: 17889509
6. Humans lack iGb3 due to the absence of functional iGb3-synthase: implications for NKT cell development and transplantation.  |  Christiansen, D., et al. 2008. PLoS Biol. 6: e172. PMID: 18630988
7. Analysis of the vitreous membrane in a case of type 1 Stickler syndrome.  |  Yokoi, T., et al. 2009. Graefes Arch Clin Exp Ophthalmol. 247: 715-8. PMID: 19089441
8. Mutation of a gene encoding a protein with extracellular matrix motifs in Usher syndrome type IIa.  |  Eudy, JD., et al. 1998. Science. 280: 1753-7. PMID: 9624053

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-iGb3 Antibody (H-7) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-iGb3 Antibody (H-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

iGb3 Antibody (H-7) Specifications

Alternate Product Name: iGb3

Product Clone Name: H-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 199-215

Epitope Target: iGb3

Epitope Species: mouse

Product Reactivity/Detection: iGb3

Species Reactivity/Detection: mouse, rat

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for iGb3 Antibody (H-7): P: Blocking Peptide

The preferred iGb3 antibody is iGb3 Antibody (D-2): sc-515685.