IgA Antibody (mAHuIgA-1&2): sc-73307
- IgA Antibody (mAHuIgA-1&2) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against IgA of human origin
- recommended for detection of both IgA1 and IgA2 subtypes of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for IgA Antibody (mAHuIgA-1&2). This work is in progress.
QUICK LINKS
SEE ALSO...
IgA Antibody (mAHuIgA-1&2) is a mouse monoclonal IgG1 antibody that detects Immunoglobulin A (IgA) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). IgA plays a crucial role in the mucosal immune system, serving as the first line of defense against pathogens that enter the body through mucosal surfaces, such as the gastrointestinal and respiratory tracts. IgA is primarily produced by B cells located in gut-associated lymphoid tissues, where daily production surpasses that of all other immunoglobulins, highlighting its importance in maintaining mucosal immunity. The structure of IgA is particularly significant, as IgA typically exists as a dimer or polymer, which allows for enhanced binding and neutralization of pathogens. This dimeric form is stabilized by a joining (J) chain and is transported to mucosal surfaces via the polymeric immunoglobulin receptor (pIgR), ensuring effective delivery where most needed to combat infections. The IgA heavy chain is an α-chain, while the light chains can be either κ- or λ- chains, contributing to IgA′s diversity and functionality. With unique structural properties and vital role in immune defense, anti-IgA antibody (mAHuIgA-1&2) is an essential tool for researchers studying mucosal immunity and related disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
IgA Antibody (mAHuIgA-1&2) References:
- Recurrent IgA nephropathy is predicted by altered glycosylated IgA, autoantibodies and soluble CD89 complexes. | Berthelot, L., et al. 2015. Kidney Int. 88: 815-22. PMID: 26061544
- Clinicopathological significance of monoclonal IgA deposition in patients with IgA nephropathy. | Nagae, H., et al. 2017. Clin Exp Nephrol. 21: 266-274. PMID: 27170372
- Peptide mimetics of immunoglobulin A (IgA) and FcαRI block IgA-induced human neutrophil activation and migration. | Heineke, MH., et al. 2017. Eur J Immunol. 47: 1835-1845. PMID: 28736835
- Serum IgA/C3 and glomerular C3 staining predict severity of IgA nephropathy. | Kawasaki, Y., et al. 2018. Pediatr Int. 60: 162-167. PMID: 29178575
- Difference in IgA1 O-glycosylation between IgA deposition donors and IgA nephropathy recipients. | Nakazawa, S., et al. 2019. Biochem Biophys Res Commun. 508: 1106-1112. PMID: 30553446
- Complement-mediated microangiopathy in IgA nephropathy and IgA vasculitis with nephritis. | Chua, JS., et al. 2019. Mod Pathol. 32: 1147-1157. PMID: 30936425
- Triptolide inhibits tonsillar IgA production by upregulating FDC-SP in IgA nephropathy. | Li, H., et al. 2020. Histol Histopathol. 35: 599-608. PMID: 31815288
- Decreased IgA binding levels were accompanied by increased IgG sialylation in IgA nephropathy. | Liu, Y., et al. 2024. Clin Nephrol. 102: 89-96. PMID: 38856027
- Determining the utility of IgA immunohistochemistry for the diagnosis of IgA vasculitis. | Ricles, V., et al. 2024. J Cutan Pathol. 51: 825-827. PMID: 38946244
- Urinary IgA in IgA nephropathy and Henoch-Schoenlein purpura. | Galla, JH., et al. 1985. J Clin Immunol. 5: 298-306. PMID: 4055989
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IgA Antibody (mAHuIgA-1&2) | sc-73307 | 100 µg/ml | $316.00 |