IgA Antibody (AD3): sc-66168
- IgA Antibody (AD3) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against purified IgA of human origin
- recommended for detection of α-chain of IgA1 and IgA2 of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for IgA Antibody (AD3). This work is in progress.
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SEE ALSO...
IgA Antibody (AD3) is a mouse monoclonal IgG1 antibody that detects Immunoglobulin A (IgA) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). IgA plays a crucial role in the mucosal immune system, serving as the first line of defense against pathogens that enter the body through mucosal surfaces, such as the gastrointestinal and respiratory tracts. IgA is primarily produced by B cells located in gut-associated lymphoid tissues, and IgA′s daily production surpasses that of all other immunoglobulins, highlighting IgA′s importance in maintaining mucosal immunity. The structure of IgA is particularly significant, as IgA typically exists as a dimer, which enhances IgA′s ability to bind to antigens and facilitates transport across mucosal surfaces via the polymeric immunoglobulin receptor. This dimeric form, along with IgA′s potential to form larger polymers, allows IgA to effectively neutralize pathogens and prevent their adherence to epithelial cells, thereby playing a vital role in immune protection. The IgA heavy chain is an α-chain, while the light chains can be either κ- or λ- chains, contributing to the diversity and specificity of the immune response. Anti-IgA antibody (AD3) is an essential tool for researchers studying mucosal immunity and the role of IgA in various diseases.
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IgA Antibody (AD3) References:
- Elevation of serum IgA in spondyloarthropathies and IgA nephropathy and its pathogenic role. | Montenegro, V. and Monteiro, RC. 1999. Curr Opin Rheumatol. 11: 265-72. PMID: 10411380
- IgA glycosylation and IgA immune complexes in the pathogenesis of IgA nephropathy. | Novak, J., et al. 2008. Semin Nephrol. 28: 78-87. PMID: 18222349
- Role of IgA and IgA fc receptors in inflammation. | Monteiro, RC. 2010. J Clin Immunol. 30: 1-9. PMID: 19834792
- IgA production and tonsillar focal infection in IgA nephropathy. | Meng, H., et al. 2012. J Clin Exp Hematop. 52: 161-70. PMID: 23269075
- IgA kappa/IgA lambda heavy/light chain assessment in the management of patients with IgA myeloma. | Boyle, EM., et al. 2014. Cancer. 120: 3952-7. PMID: 25116271
- IgA binding factors and Fc receptors for IgA: comparative studies between IgA and IgE Fc receptor systems. | Yodoi, J., et al. 1987. Int Rev Immunol. 2: 117-41. PMID: 2976802
- MYD88L265P mutated IgA lymphoplasmacytic lymphoma. | Urquieta Lam, M., et al. 2019. Histopathology. 75: 608-612. PMID: 31107988
- IgA Antibodies and IgA Deficiency in SARS-CoV-2 Infection. | Quinti, I., et al. 2021. Front Cell Infect Microbiol. 11: 655896. PMID: 33889552
- Current understanding of IgA antibodies in the pathogenesis of IgA nephropathy. | Nihei, Y., et al. 2023. Front Immunol. 14: 1165394. PMID: 37114051
- Clinical and histological comparison of IgA nephritis and renal IgA vasculitis. | Friedrich, J., et al. 2024. Nephrol Dial Transplant. 40: 182-192. PMID: 38908911
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IgA Antibody (AD3) | sc-66168 | 100 µg/ml | $316.00 |