IgA Antibody (A2A-13): sc-69911
- IgA Antibody (A2A-13) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against IgA of human origin
- recommended for detection of IgA of human origin by WB, IP and ELISA; non cross-reactive with human IgE, IgG or IgM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for IgA Antibody (A2A-13). This work is in progress.
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IgA Antibody (A2A-13) is a mouse monoclonal IgG1 antibody that detects Immunoglobulin A (IgA) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). IgA plays a crucial role in the mucosal immune system, serving as the first line of defense against pathogens that enter the body through mucosal surfaces, such as the gastrointestinal and respiratory tracts. IgA is primarily produced by B cells located in gut-associated lymphoid tissues, where daily production surpasses that of all other immunoglobulins, highlighting its importance in maintaining mucosal immunity. The structure of IgA is particularly significant, as IgA typically exists as a dimer, which enhances binding to pathogens and neutralizes them effectively. This dimeric form is stabilized by a joining (J) chain and is transported to mucosal surfaces via the polymeric immunoglobulin receptor (pIgR), ensuring IgA is readily available where most needed. The IgA heavy chain is an α-chain, while the light chains can be either κ- or λ- chains, contributing to the diversity of IgA molecules. With its unique structure and function, IgA is essential for protecting mucosal surfaces from infections, making anti-IgA antibody (A2A-13) a valuable tool for researchers studying immune responses and mucosal health.
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IgA Antibody (A2A-13) References:
- Pathogenic significance of IgA receptor interactions in IgA nephropathy. | Monteiro, RC., et al. 2002. Trends Mol Med. 8: 464-8. PMID: 12383768
- International IgA nephropathy network clinico-pathological classification of IgA nephropathy. | Feehally, J., et al. 2007. Contrib Nephrol. 157: 13-8. PMID: 17495432
- Autoimmunity in IgA deficiency: revisiting the role of IgA as a silent housekeeper. | Jacob, CM., et al. 2008. J Clin Immunol. 28 Suppl 1: S56-61. PMID: 18202833
- The glomerular response to IgA deposition in IgA nephropathy. | Moura, IC., et al. 2008. Semin Nephrol. 28: 88-95. PMID: 18222350
- Diffuse panbronchiolitis and IgA nephropathy. | Tossier, C., et al. 2014. Am J Respir Crit Care Med. 189: 106-9. PMID: 24381993
- Lymphoplasmacytic Lymphoma with IgA Paraproteinemia. | Guan, J., et al. 2015. Clin Lab. 61: 835-7. PMID: 26299085
- Scarcity of autoreactive human blood IgA+ memory B cells. | Prigent, J., et al. 2016. Eur J Immunol. 46: 2340-2351. PMID: 27469325
- Serum Soluble CD89-IgA Complexes Are Elevated in IgA Nephropathy without Immunosuppressant History. | Wu, H., et al. 2020. Dis Markers. 2020: 8393075. PMID: 32076466
- Immunoglobulin A (IgA): molecular and cellular interactions involved in IgA biosynthesis and immune response. | Mestecky, J. and McGhee, JR. 1987. Adv Immunol. 40: 153-245. PMID: 3296685
- Gut Microbiota Perturbation in IgA Deficiency Is Influenced by IgA-Autoantibody Status. | Moll, JM., et al. 2021. Gastroenterology. 160: 2423-2434.e5. PMID: 33662387
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IgA Antibody (A2A-13) | sc-69911 | 100 µg/ml | $316.00 |