Ig λ chain Antibody (48): sc-52339

Ig λ chain Antibody (48) is a mouse monoclonal IgG1 kappa light chain antibody that detects the Ig λ Chain protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). Anti-Ig λ chain antibody (48) is available in a non-conjugated form, providing flexibility for various experimental needs. The Ig λ chain plays a crucial role in the immune response, as one of the two types of light chains that pair with heavy chains to form functional antibodies. These antibodies are essential for recognizing and neutralizing foreign antigens, protecting the body from infections and diseases. The structure of immunoglobulins consists of two identical heavy chains and two identical light chains linked by disulfide bonds, allowing for specific binding of antigens. The unique variable regions of the light chains, including the λ chain, contribute to the diversity of the antibody repertoire, enabling the immune system to respond to various pathogens. The λ light chain genes are located on chromosome 22, and their expression is tightly regulated during B cell development, ensuring each B cell produces a single type of light chain. This specificity maintains the integrity of the immune response, preventing the production of antibodies that could target the body′s own tissues.

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Ig λ chain Antibody (48) References:

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2. Imprint of somatic hypermutation differs in human immunoglobulin heavy and lambda chain variable gene segments.  |  Boursier, L., et al. 2003. Mol Immunol. 39: 1025-34. PMID: 12749909
3. Expression of immunoglobulin kappa light chain constant region in abnormal human cervical epithelial cells.  |  Li, M., et al. 2004. Int J Biochem Cell Biol. 36: 2250-7. PMID: 15313470
4. Monoclonal antibodies against human leucocyte antigens. I. Antibodies against beta-2-microglobulin, immunoglobulin kappa light chains, HLA-DR-like antigens, T8 antigen, T1 antigen, a monocyte antigen, and a pan-leucocyte antigen.  |  Horejsí, V., et al. 1986. Folia Biol (Praha). 32: 12-25. PMID: 2422063
5. Cord Blood Proteomic Biomarkers for Predicting Adverse Neurodevelopmental Outcomes in Monoamniotic Twins.  |  Jung, YM., et al. 2022. Reprod Sci. 29: 1756-1763. PMID: 35165813
6. Complement C3 is downregulated following ranibizumab intervention in experimental central retinal vein occlusion.  |  Cehofski, LJ., et al. 2024. Mol Vis. 30: 268-277. PMID: 39563678
7. Multiple expression of Ig lambda-chain encoding RNA species in murine plasmacytoma cells.  |  Schwartz, RC., et al. 1981. J Immunol. 126: 2104-8. PMID: 6164720
8. Evolution of human immunoglobulin kappa J region genes.  |  Hieter, PA., et al. 1982. J Biol Chem. 257: 1516-22. PMID: 6276389
9. Novel kappa light-chain gene rearrangements in mouse lambda light chain-producing B lymphocytes.  |  Durdik, J., et al. Nature. 307: 749-52. PMID: 6422305
10. The rat mixed lymphocyte reaction: roles of a dendritic cell in intestinal lymph and T-cell subsets defined by monoclonal antibodies.  |  Mason, DW., et al. 1981. Immunology. 44: 75-87. PMID: 6456222
11. Cloned human and mouse kappa immunoglobulin constant and J region genes conserve homology in functional segments.  |  Hieter, PA., et al. 1980. Cell. 22: 197-207. PMID: 6775818
12. Committed T lymphocyte stem cells of rats. Characterization by surface W3/13 antigen and radiosensitivity.  |  Dyer, MJ. and Hunt, SV. 1981. J Exp Med. 154: 1164-77. PMID: 6974759

The preferred Ig λ chain antibody is Ig λ chain Antibody (N10/2): sc-53344.