IFN-γ/Interferon gamma Antibody (G-30): sc-57208

IFN-γ Antibody (G-30) is a mouse monoclonal IgG1 kappa light chain antibody that detects IFN-γ in mouse, rat, and human samples through western blotting (WB) and immunoprecipitation (IP). IFN-γ Antibody (G-30) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing versatility for different experimental needs. Interferon gamma (IFN-γ) plays a crucial role in the immune response, acting as a potent antiviral and antiparasitic agent produced primarily by activated CD4+/CD8+ lymphocytes and natural killer cells. IFN-γ modulates T cell growth and differentiation while inhibiting B cell proliferation, thereby influencing the overall immune response. IFN-γ synthesis is induced by various cytokines, including interleukin-2, fibroblast growth factor, and epidermal growth factor, highlighting its importance in immune regulation. Structurally, the active form of IFN-γ is a homodimer, with each subunit comprising six helices, and the stability of this dimeric structure is maintained through non-covalent interactions at the helices′ interface. The precursor of IFN-γ consists of 166 amino acids, which includes a 23 amino acid secretory sequence, and IFN-γ functional diversity is further enhanced by variable glycosylation and the formation of dimers and tetramers under non-denaturing conditions.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IFN-γ/Interferon gamma Antibody (G-30) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-IFN-γ/Interferon gamma Antibody (G-30) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IFN-γ/Interferon gamma Antibody (G-30) Specifications

Alternate Product Name: IFN-γ

Product Clone Name: G-30

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: IFN-γ

Epitope Species: human

Product Reactivity/Detection: IFN-γ

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for IFN-γ/Interferon gamma Antibody (G-30): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred IFN-γ/Interferon gamma antibody is IFN-γ/Interferon gamma Antibody (G-23): sc-8423.