IFN-γ/Interferon gamma Antibody (A-9): sc-390800

IFN-γ Antibody (A-9) is a mouse monoclonal IgG1 antibody that detects Interferon (IFN)-γ in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IFN-γ plays a crucial role in the immune response, acting as an antiviral and antiparasitic agent produced by activated CD4+/CD8+ lymphocytes and natural killer cells. IFN-γ modulates T cell growth and differentiation while inhibiting B cell proliferation, thereby shaping the adaptive immune response. IFN-γ′s active form is a homodimer, with each subunit comprising six helices, and this dimeric structure is stabilized by non-covalent interactions at the interface of the helices. IFN-γ precursor consists of 166 amino acids, which includes a 23 amino acid secretory sequence, and IFN-γ functionality is further enhanced by various post-translational modifications, including glycosylation, leading to multiple forms under non-denaturing conditions, such as dimers and tetramers. IFN-γ′s versatility in immune regulation underscores its significance in therapeutic applications and research, making anti-IFN-γ antibody (A-9) an essential tool for studying immune responses in human samples.

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Contains Mercury: All HRP conjugates (including bundle forms) contain thiomersal, a mercury compound. Do not dispose in trash. Dispose as hazardous chemical waste according to local, state and federal regulations.

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IFN-γ/Interferon gamma Antibody (A-9) References:

1. B7-DC regulates asthmatic response by an IFN-gamma-dependent mechanism.  |  Matsumoto, K., et al. 2004. J Immunol. 172: 2530-41. PMID: 14764726
2. Regulation of hair regrowth in alopecic site of IFN-gamma-/- mice by macrophages infiltrating into allograft in IFN-gamma+/+ mice.  |  Okada, M., et al. 2005. J Interferon Cytokine Res. 25: 564-74. PMID: 16181057
3. Induced expression of murine gamma2a by CD40 ligation independently of IFN-gamma.  |  Collins, JT., et al. 2006. J Immunol. 177: 5414-9. PMID: 17015727
4. CD8(+) T cells armed with retrovirally transduced IFN-gamma.  |  Becker, C., et al. 2007. J Mol Med (Berl). 85: 63-73. PMID: 17109130
5. IFN-gamma enhances secretion of IgG2a from IgG2a-committed LPS-stimulated murine B cells: implications for the role of IFN-gamma in class switching.  |  Bossie, A. and Vitetta, ES. 1991. Cell Immunol. 135: 95-104. PMID: 1902147
6. Balance of Irgm protein activities determines IFN-gamma-induced host defense.  |  Henry, SC., et al. 2009. J Leukoc Biol. 85: 877-85. PMID: 19176402
7. Reduced IFN-γ receptor expression and attenuated IFN-γ response by dendritic cells in patients with atopic dermatitis.  |  Gros, E., et al. 2011. J Allergy Clin Immunol. 128: 1015-21. PMID: 21774972
8. Sphingosine Kinase 2 Deficiency Attenuates Kidney Fibrosis via IFN-γ.  |  Bajwa, A., et al. 2017. J Am Soc Nephrol. 28: 1145-1161. PMID: 27799486
9. Noncanonical Fungal Autophagy Inhibits Inflammation in Response to IFN-γ via DAPK1.  |  Oikonomou, V., et al. 2016. Cell Host Microbe. 20: 744-757. PMID: 27889463
10. Normal and keloid fibroblasts are differentially influenced by IFN-γ and triamcinolone as well as by their combination.  |  Euler, T., et al. 2019. Wound Repair Regen. 27: 450-461. PMID: 30994217

The preferred IFN-γ/Interferon gamma antibody is IFN-γ/Interferon gamma Antibody (G-23): sc-8423.