IFN-α/βRα Antibody (E-12): sc-393089

IFN-α/βRα Antibody (E-12) is a mouse monoclonal IgG2a kappa light chain antibody that detects IFN-α/βRα in mouse and rat samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-IFN-α/βRα antibody (E-12) is available in both non-conjugated and multiple conjugated forms, such as agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and various Alexa Fluor® conjugates. IFN-α/βRα plays a crucial role in the immune response as part of the type I interferon receptor complex that mediates the antiviral effects of interferons α and β. These interferons are vital for initiating an immune response against viral infections by activating signaling pathways that lead to the expression of antiviral proteins and enhance the overall immune response. Binding of type I interferons to IFN-α/βRα triggers a cascade of intracellular signaling events, primarily through the activation of the Janus kinase 1 (JAK1) and signal transducer and activator of transcription (STAT) pathways, which are essential for the regulation of genes involved in immune defense. Structural integrity of IFN-α/βRα is critical for function, as any alterations can significantly impact interferon binding and signaling pathway initiation, thereby influencing host susceptibility to viral infections.

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IFN-α/βRα Antibody (E-12) References:

1. IFN-alpha and IFN-beta: a link between immune memory and chronic inflammation.  |  Akbar, AN., et al. 2000. Immunol Today. 21: 337-42. PMID: 10871875
2. Ingested IFN-alpha preserves residual beta cell function in type 1 diabetes.  |  Brod, SA., et al. 2001. J Interferon Cytokine Res. 21: 1021-30. PMID: 11798459
3. New aspects of IFN-alpha/beta signalling in immunity, oncogenesis and bone metabolism.  |  Takaoka, A. and Taniguchi, T. 2003. Cancer Sci. 94: 405-11. PMID: 12824884
4. IFN-α induces IL-10 production and tilt the balance between Th1 and Th17 in Behçet disease.  |  Touzot, M., et al. 2015. Autoimmun Rev. 14: 370-5. PMID: 25541082
5. Control of HIV infection by IFN-α: implications for latency and a cure.  |  Bourke, NM., et al. 2018. Cell Mol Life Sci. 75: 775-783. PMID: 28988399
6. CCR2 Signaling Selectively Regulates IFN-α: Role of β-Arrestin 2 in IFNAR1 Internalization.  |  Williams, DW., et al. 2019. J Immunol. 202: 105-118. PMID: 30504423
7. Impact and prognosis of the expression of IFN-α among tuberculosis patients.  |  Taneja, V., et al. 2020. PLoS One. 15: e0235488. PMID: 32667932
8. IFN-α: A key therapeutic target for multiple autoimmune rheumatic diseases.  |  De Ceuninck, F., et al. 2021. Drug Discov Today. 26: 2465-2473. PMID: 34224903
9. Curcumin assists anti-EV71 activity of IFN-α by inhibiting IFNAR1 reduction in SH-SY5Y cells.  |  Wang, Y., et al. 2022. Gut Pathog. 14: 8. PMID: 35151347
10. Inhibiting cell-to-cell transmission to reach HDV cure: The importance of IFN-α.  |  Lucifora, J., et al. 2022. J Hepatol. 77: 903-905. PMID: 35952820

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IFN-α/βRα Antibody (E-12) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-IFN-α/βRα Antibody (E-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IFN-α/βRα Antibody (E-12) Specifications

Alternate Product Name: IFN-α/βRα

Product Clone Name: E-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 551-589

Epitope Target: IFN-α/βRα

Epitope Species: mouse

Product Reactivity/Detection: IFN-α/βRα

Species Reactivity/Detection: mouse, rat

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for IFN-α/βRα Antibody (E-12): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred IFN-α/βRα antibody is IFN-α/βRα Antibody (H-11): sc-7391.