IFITM1/2/3 Antibody (F-12): sc-374026

IFITM1/2/3 Antibody (F-12) is a mouse monoclonal IgG1 kappa light chain antibody that detects IFITM1/2/3 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). IFITM1/2/3 (F-12) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The Interferon-Inducible Transmembrane (IFITM) proteins play a crucial role in immune response, particularly in viral infections, as IFITM proteins restrict entry of various viruses into host cells. IFITM proteins are located in the cell membrane and upregulated in response to interferon signaling, which is vital for host defense mechanisms. IFITM proteins at the cell surface allow immediate interaction with viral particles, preventing fusion with host cell membrane and subsequent infection. IFITM family has been implicated in modulating cell adhesion and influencing cell differentiation, particularly in primordial germ cells, where IFITM1 acts as a repulsive molecule, guiding migration of these cells during development. Upregulation of IFITM proteins in human colorectal carcinomas highlights their potential role in cancer biology, making anti-IFITM1/2/3 antibody (F-12) a valuable tool for researchers studying both viral pathogenesis and cancer.

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IFITM1/2/3 Antibody (F-12) References:

1. Cloning of interferon-stimulated gene 17: the promoter and nuclear proteins that regulate transcription.  |  Perry, DJ., et al. 1999. Mol Endocrinol. 13: 1197-206. PMID: 10406469
2. A molecular programme for the specification of germ cell fate in mice.  |  Saitou, M., et al. 2002. Nature. 418: 293-300. PMID: 12124616
3. Expression of IFITM1 in chronic myeloid leukemia patients.  |  Akyerli, CB., et al. 2005. Leuk Res. 29: 283-6. PMID: 15661263
4. IFITM1-mediated cell repulsion controls the initial steps of germ cell migration in the mouse.  |  Wylie, C. 2005. Dev Cell. 9: 723-4. PMID: 16326382
5. IFITM/Mil/fragilis family proteins IFITM1 and IFITM3 play distinct roles in mouse primordial germ cell homing and repulsion.  |  Tanaka, SS., et al. 2005. Dev Cell. 9: 745-56. PMID: 16326387
6. Identification of the IFITM family as a new molecular marker in human colorectal tumors.  |  Andreu, P., et al. 2006. Cancer Res. 66: 1949-55. PMID: 16488993
7. A single DNA response element can confer inducibility by both alpha- and gamma-interferons.  |  Reid, LE., et al. 1989. Proc Natl Acad Sci U S A. 86: 840-4. PMID: 2492664
8. The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer's disease.  |  Hur, JY., et al. 2020. Nature. 586: 735-740. PMID: 32879487
9. Interaction of SERINC5 and IFITM1/2/3 regulates the autophagy-apoptosis-immune network under CSFV infection.  |  Li, W., et al. 2022. Virulence. 13: 1720-1740. PMID: 36205528
10. Interferon-induced transmembrane protein 3 (IFITM3) limits lethality of SARS-CoV-2 in mice.  |  Kenney, AD., et al. 2023. EMBO Rep. 24: e56660. PMID: 36880581
11. IFITM3 blocks influenza virus entry by sorting lipids and stabilizing hemifusion.  |  Klein, S., et al. 2023. Cell Host Microbe. 31: 616-633.e20. PMID: 37003257
12. Expression cloning of an interferon-inducible 17-kDa membrane protein implicated in the control of cell growth.  |  Deblandre, GA., et al. 1995. J Biol Chem. 270: 23860-6. PMID: 7559564

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IFITM1/2/3 Antibody (F-12) has 10 citations in a variety of scientific publications.

Primary antibodies like Anti-IFITM1/2/3 Antibody (F-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IFITM1/2/3 Antibody (F-12) Specifications

Alternate Product Name: IFITM1

Product Clone Name: F-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-125

Epitope Target: IFITM1

Epitope Species: human

Product Reactivity/Detection: IFITM1, IFITM2 and IFITM3

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 10 citations in various scientific publications

Available Conjugates/Forms for IFITM1/2/3 Antibody (F-12): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin