IFI-202 Antibody (F-7): sc-166253

IFI-202 Antibody (F-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects IFI-202 protein of mouse origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). IFI-202 (F-7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. IFI-202 plays a crucial role in immune response regulation, primarily functioning as a nuclear phosphoprotein that inhibits cell growth by modulating transcriptional activity of key regulatory proteins such as NFκB, E2F, AP-1, and p53. This inhibition helps control cellular proliferation and apoptosis, thereby influencing immune response and potentially impacting cancer progression. IFI-202 belongs to a larger family of interferon-inducible proteins, including IFI-203, IFI-204, and D3, all encoded by genes located in the q21-q23 region of chromosome 1. These proteins share homologous segments, highlighting their evolutionary relationship and functional similarities. Two related human proteins, MNDA (myeloid cell nuclear differentiation antigen) and IFI-16, have been identified, with MNDA being specifically expressed in granulocyte-macrophage lineage cells and IFI-16 being constitutively expressed in various T and B cell lines, further underscoring IFI-202′s importance in immune regulation.

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IFI-202 Antibody (F-7) References:

1. The human myeloid cell nuclear differentiation antigen gene is one of at least two related interferon-inducible genes located on chromosome 1q that are expressed specifically in hematopoietic cells.  |  Briggs, RC., et al. 1994. Blood. 83: 2153-62. PMID: 7512843
2. IFI 16 gene encodes a nuclear protein whose expression is induced by interferons in human myeloid leukaemia cell lines.  |  Dawson, MJ. and Trapani, JA. 1995. J Cell Biochem. 57: 39-51. PMID: 7536752
3. A lipopolysaccharide-inducible macrophage gene (D3) is a new member of an interferon-inducible gene cluster and is selectively expressed in mononuclear phagocytes.  |  Tannenbaum, CS., et al. 1993. J Leukoc Biol. 53: 563-8. PMID: 7684766
4. The interferon-inducible p202 protein as a modulator of transcription: inhibition of NF-kappa B, c-Fos, and c-Jun activities.  |  Min, W., et al. 1996. Mol Cell Biol. 16: 359-68. PMID: 8524315
5. Characterization of the human myeloid cell nuclear differentiation antigen gene promoter.  |  Kao, WY., et al. 1996. Biochim Biophys Acta. 1308: 201-4. PMID: 8809111
6. Inhibition of E2F-mediated transcription by p202.  |  Choubey, D., et al. 1996. EMBO J. 15: 5668-78. PMID: 8896460
7. p202, an interferon-inducible modulator of transcription, inhibits transcriptional activation by the p53 tumor suppressor protein, and a segment from the p53-binding protein 1 that binds to p202 overcomes this inhibition.  |  Datta, B., et al. 1996. J Biol Chem. 271: 27544-55. PMID: 8910340

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IFI-202 Antibody (F-7) has 6 citations in a variety of scientific publications.

Primary antibodies like Anti-IFI-202 Antibody (F-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IFI-202 Antibody (F-7) Specifications

Alternate Product Name: IFI-202

Product Clone Name: F-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 316-385

Epitope Target: IFI-202

Epitope Species: mouse

Product Reactivity/Detection: IFI-202a and IFI-202b

Species Reactivity/Detection: mouse

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 6 citations in various scientific publications

Available Conjugates/Forms for IFI-202 Antibody (F-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin