IdeE2 Antibody (C-1): sc-514333
- IdeE2 Antibody (C-1) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 1-385 representing full length IdeE2 of Streptococcus equi subsp. equi origin
- IdeE2 Antibody (C-1) is recommended for detection of IdeE2 of S. equi subsp. equi 4047 origin of Streptococcus equi origin by WB, IP, IF and ELISA
- Anti-IdeE2 Antibody (C-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for IdeE2 Antibody (C-1) for WB applications. These reagents are now offered in bundles with IdeE2 Antibody (C-1) (see ordering information below).
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IdeE2 Antibody (C-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects IdeE2 from Streptococcus equi subsp. equi 4047 by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IdeE2 antibody (C-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. IdeE2 plays a crucial role in the pathogenesis of strangles, a highly contagious disease affecting horses, as IdeE2 is involved in the evasion of the host′s immune response. By interfering with the host′s immune signaling pathways, IdeE2 allows Streptococcus equi to persist and proliferate, leading to severe inflammatory responses characterized by lymphadenopathy, fever, nasal discharge, and anorexia in affected horses. Understanding IdeE2 function is vital for developing effective treatments and vaccines against strangles, particularly since young horses are more susceptible due to their underdeveloped immune systems.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
IdeE2 Antibody (C-1) References:
- Streptococcus equi with truncated M-proteins isolated from outwardly healthy horses. | Chanter, N., et al. 2000. Microbiology (Reading). 146 (Pt 6): 1361-1369. PMID: 10846214
- The molecular basis of Streptococcus equi infection and disease. | Harrington, DJ., et al. 2002. Microbes Infect. 4: 501-10. PMID: 11932201
- The pathogenic equine streptococci. | Timoney, JF. 2004. Vet Res. 35: 397-409. PMID: 15236673
- Lack of correlation between antibody titers to fibrinogen-binding protein of Streptococcus equi and persistent carriers of strangles. | Davidson, A., et al. 2008. J Vet Diagn Invest. 20: 457-62. PMID: 18599850
- Genomic evidence for the evolution of Streptococcus equi: host restriction, increased virulence, and genetic exchange with human pathogens. | Holden, MT., et al. 2009. PLoS Pathog. 5: e1000346. PMID: 19325880
- Two novel IgG endopeptidases of Streptococcus equi. | Hulting, G., et al. 2009. FEMS Microbiol Lett. 298: 44-50. PMID: 19659725
- Streptococcus equi: a pathogen restricted to one host. | Waller, AS., et al. 2011. J Med Microbiol. 60: 1231-1240. PMID: 21757503
- Streptococcus equi subspecies equi infection (strangles) in horses. | Boyle, A. 2011. Compend Contin Educ Vet. 33: E1-7; quiz E8. PMID: 21870348
- Comparison of specificities of serum antibody responses of horses to clinical infections caused by Streptococcus equi or zooepidemicus. | Velineni, S., et al. 2015. Vet Microbiol. 180: 253-9. PMID: 26386491
- Characterisation of SEQ0694 (PrsA/PrtM) of Streptococcus equi as a functional peptidyl-prolyl isomerase affecting multiple secreted protein substrates. | Ikolo, F., et al. 2015. Mol Biosyst. 11: 3279-86. PMID: 26466087
- Prophylaxis in contacts of patients with rabies. | Hoffer, J. 1979. N Engl J Med. 301: 1451. PMID: 514333
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IdeE2 Antibody (C-1) | sc-514333 | 200 µg/ml | $316.00 | |||
IdeE2 Antibody (C-1): m-IgG Fc BP-HRP Bundle | sc-527887 | 200 µg Ab; 10 µg BP | $354.00 | |||
IdeE2 Antibody (C-1): m-IgG1 BP-HRP Bundle | sc-533260 | 200 µg Ab; 20 µg BP | $354.00 | |||
IdeE2 Antibody (C-1) AC | sc-514333 AC | 500 µg/ml, 25% agarose | $416.00 | |||
IdeE2 Antibody (C-1) HRP | sc-514333 HRP | 200 µg/ml | $316.00 | |||
IdeE2 Antibody (C-1) FITC | sc-514333 FITC | 200 µg/ml | $330.00 | |||
IdeE2 Antibody (C-1) PE | sc-514333 PE | 200 µg/ml | $343.00 | |||
IdeE2 Antibody (C-1) Alexa Fluor® 488 | sc-514333 AF488 | 200 µg/ml | $357.00 | |||
IdeE2 Antibody (C-1) Alexa Fluor® 546 | sc-514333 AF546 | 200 µg/ml | $357.00 | |||
IdeE2 Antibody (C-1) Alexa Fluor® 594 | sc-514333 AF594 | 200 µg/ml | $357.00 | |||
IdeE2 Antibody (C-1) Alexa Fluor® 647 | sc-514333 AF647 | 200 µg/ml | $357.00 | |||
IdeE2 Antibody (C-1) Alexa Fluor® 680 | sc-514333 AF680 | 200 µg/ml | $357.00 | |||
IdeE2 Antibody (C-1) Alexa Fluor® 790 | sc-514333 AF790 | 200 µg/ml | $357.00 |