Id2 Antibody (2457C5a): sc-81298
- Id2 Antibody (2457C5a) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against a recombinant protein corresponding to a region near the N-terminus of Id2 of human origin
- recommended for detection of Id2 of human origin by WB and IP
- See Id2 (E-7): sc-398104 for Id2 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Id2 Antibody (2457C5a). This work is in progress.
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Id2 Antibody (2457C5a) is a mouse monoclonal IgG1 antibody that detects Id2 in human samples through applications such as western blotting (WB) and immunoprecipitation (IP). Id2 is a member of the Id family of basic helix-loop-helix (bHLH) proteins, which play a crucial role in regulating cell differentiation and proliferation. Id2 (2457C5a) antibody recognizes a protein known to inhibit the DNA binding activity of class A and B bHLH proteins, thereby preventing the transcription of genes necessary for muscle differentiation. This function is particularly important as Id2 allows for the regulation of muscle-specific gene expression during the cell cycle. Under conditions that promote muscle cell differentiation, Id2 levels decrease, enabling the formation of active heterodimers with proteins such as Myo D and myogenin, which are essential for initiating myogenic differentiation. Furthermore, Id2 expression is tightly regulated by growth factors, and studies have shown that reducing Id2 mRNA levels can delay the reentry of quiescent cells into the cell cycle following growth factor stimulation. This highlights the significance of Id2 not only in muscle development but also in broader cellular processes, making anti-Id2 antibody (2457C5a) a valuable tool for researchers studying these critical pathways.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Id2 Antibody (2457C5a) References:
- In vivo genome-wide binding of Id2 to E2F4 target genes as part of a reversible program in mice liver. | Ferrer-Vicens, I., et al. 2014. Cell Mol Life Sci. 71: 3583-97. PMID: 24573694
- Id2 Represses Aldosterone-Stimulated Cardiac T-Type Calcium Channels Expression. | Ito, J., et al. 2021. Int J Mol Sci. 22: PMID: 33808082
- ID2 inhibits innate antiviral immunity by blocking TBK1- and IKKε-induced activation of IRF3. | Yu, C., et al. 2022. Sci Signal. 15: eabh0068. PMID: 34982578
- ID2 controls differentiation of enteroendocrine cells in mouse small intestine. | Zinina, VV., et al. 2022. Acta Physiol (Oxf). 234: e13773. PMID: 34985199
- Regulation and function of Id2 in plasmacytoid dendritic cells. | Babcock, RL., et al. 2022. Mol Immunol. 148: 6-17. PMID: 35640521
- ID2 and HIF-1α collaborate to protect quiescent hematopoietic stem cells from activation, differentiation, and exhaustion. | Jakubison, BL., et al. 2022. J Clin Invest. 132: PMID: 35775482
- Id2 exerts tumor suppressor properties in lung cancer through its effects on cancer cell invasion and migration. | Chen, JT., et al. 2022. Front Oncol. 12: 801300. PMID: 35982951
- Id2 GABAergic interneurons comprise a neglected fourth major group of cortical inhibitory cells. | Machold, R., et al. 2023. Elife. 12: PMID: 37665123
- ID2 Promotes Lineage Transition of Prostate Cancer through FGFR and JAK-STAT Signaling. | Zhang, J., et al. 2024. Cancers (Basel). 16: PMID: 38254880
- Id2 epigenetically controls CD8+ T-cell exhaustion by disrupting the assembly of the Tcf3-LSD1 complex. | Li, Y., et al. 2024. Cell Mol Immunol. 21: 292-308. PMID: 38287103
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Id2 Antibody (2457C5a) | sc-81298 | 100 µg/ml | $339.00 |