ICAT Antibody (5C6): sc-293489
- ICAT Antibody (5C6) is a mouse monoclonal IgG1 κ ICAT antibody, cited in 1 publications, provided at 100 µg/ml
- raised against amino acids 1-81 representing partial length ICAT of human origin
- recommended for detection of ICAT of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for ICAT Antibody (5C6). This work is in progress.
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ICAT Antibody (5C6) is a mouse monoclonal IgG1 kappa light chain antibody that detects ICAT protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-ICAT antibody (5C6) is available as the non-conjugated monoclonal isotype antibody. ICAT protein plays a crucial role in regulating the Wnt signaling pathway by directly interacting with β-catenin, thereby inhibiting its association with TCF-4 and blocking β-catenin–TCF-4-mediated transactivation. This regulatory function is particularly important as ICAT has been shown to suppress tumor cell proliferation, making ICAT a potential target for cancer therapies. Additionally, ICAT induces G2 arrest followed by cell death in colorectal tumor cells, highlighting ICAT′s significance in cancer biology. The structural characteristics of ICAT include a three-helix bundle and a C-terminal tail, which are essential for ICAT′s interaction with β-catenin and regulatory functions. The gene encoding human ICAT is located on chromosome 1p36.22, further emphasizing ICAT′s relevance in genetic studies and potential implications in various diseases.
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ICAT Antibody (5C6) References:
- Inhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting protein. | Tago, K., et al. 2000. Genes Dev. 14: 1741-9. PMID: 10898789
- Overexpression of Icat induces G(2) arrest and cell death in tumor cell mutants for adenomatous polyposis coli, beta-catenin, or Axin. | Sekiya, T., et al. 2002. Cancer Res. 62: 3322-6. PMID: 12036951
- Molecular genetic analysis of malignant melanomas for aberrations of the WNT signaling pathway genes CTNNB1, APC, ICAT and BTRC. | Reifenberger, J., et al. 2002. Int J Cancer. 100: 549-56. PMID: 12124804
- The crystal structure of the beta-catenin/ICAT complex reveals the inhibitory mechanism of ICAT. | Graham, TA., et al. 2002. Mol Cell. 10: 563-71. PMID: 12408824
- Ectopic expression of Axin blocks neuronal differentiation of embryonic carcinoma P19 cells. | Lyu, J., et al. 2003. J Biol Chem. 278: 13487-95. PMID: 12569091
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ICAT Antibody (5C6) | sc-293489 | 100 µg/ml | $316.00 |