ICAM-3 Antibody (F-11): sc-365456

ICAM-3 Antibody (F-11) is a mouse monoclonal IgG1 antibody that detects ICAM-3 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ICAM-3, also known as CD50 and ICAM-R, is a type I membrane protein that plays a crucial role in cell adhesion and immune response by facilitating interactions between leukocytes and endothelial cells. Anti-ICAM-3 antibody (F-11) recognizes a protein primarily located on the surface of immune cells, where ICAM-3 acts as a counter-receptor for the leukocyte integrin αL/β2, thereby promoting T cell activation and enhancing the immune response. Additionally, ICAM-3 interacts with Moesin, a protein that links the cytoskeleton to the plasma membrane, which is essential for maintaining cell shape and motility. ICAM-3 expression is upregulated by RANTES, a chemokine that attracts T lymphocytes to sites of inflammation, highlighting ICAM-3′s importance in immune surveillance and response. ICAM-3 monoclonal antibody (F-11) enables researchers to gain valuable insights into the mechanisms of cell adhesion and immune activation, contributing to a better understanding of various physiological and pathological processes.

The preferred ICAM-3 antibody is ICAM-3 Antibody (CG106): sc-53338.