ICAM-1/CD54 Antibody (P2A4): sc-18839

ICAM-1 Antibody (P2A4) is a mouse monoclonal IgG1 kappa light chain antibody raised against IL-1β activated human vascular endothelial cells expressing ICAM-1, demonstrating reactivity with human species. Anti-ICAM-1 antibody (P2A4) is suitable for applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). ICAM-1, also known as CD54 or intercellular adhesion molecule-1, is a type I transmembrane glycoprotein belonging to the immunoglobulin superfamily. ICAM-1 plays a crucial role in immune responses by mediating leukocyte adhesion and transmigration across the endothelium during inflammation. ICAM-1 undergoes post-translational modifications such as N-linked glycosylation, which are important for stability, cell surface expression, and interaction with integrins like LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18) on leukocytes. These modifications can affect ICAM-1′s function in cell adhesion and signaling pathways. Altered expression or glycosylation patterns of ICAM-1 are associated with various pathological conditions, including autoimmune diseases, cardiovascular disorders, and cancer metastasis. Understanding ICAM-1′s role and post-translational modifications is essential for research into inflammatory processes and potential therapeutic interventions.

The preferred ICAM-1/CD54 antibody is ICAM-1/CD54 Antibody (G-5): sc-8439.