ICAM-1/CD54 Antibody (1A29): sc-19584

ICAM-1 Antibody (1A29) is a mouse monoclonal IgG1 kappa light chain antibody raised against a suspension of HEV-derived Ax cell line of rat origin, demonstrating reactivity with mouse, rat, and human species. ICAM-1 (1A29) monoclonal antibody works effectively in immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). ICAM-1, also known as CD54 or intercellular adhesion molecule-1, is a cell surface glycoprotein belonging to the immunoglobulin superfamily that plays a crucial role in mediating cell-cell adhesion during immune responses. ICAM-1 specifically interacts with integrins such as LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18) on leukocytes, facilitating their adhesion and transmigration across the endothelium. This interaction is vital for immune surveillance, inflammation, and the initiation of immune responses. ICAM-1 also interacts with proteins like fibrinogen and hyaluronan-binding protein 2, influencing cellular signaling pathways and vascular permeability. Understanding these protein-protein interactions helps advance research into inflammatory diseases, autoimmune disorders, and cancer metastasis, where altered ICAM-1 expression and function contribute to disease progression.

The preferred ICAM-1/CD54 antibody is ICAM-1/CD54 Antibody (G-5): sc-8439.