ICAM-1/CD54 Antibody (1A29): sc-19584
- ICAM-1/CD54 Antibody (1A29) is a mouse monoclonal IgG1 κ, cited in 6 publications, provided at 200 µg/ml
- raised against a suspension of HEV-derived Ax cell line of rat origin
- recommended for detection of ICAM-1 of mouse, rat and human origin by IF, IHC(P) and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also provided azide-free for blocking, sc-19584 L, 200 µg/0.1 ml
- See ICAM-1/CD54 (G-5): sc-8439 for ICAM-1/CD54 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for ICAM-1/CD54 Antibody (1A29) for IHC(P) applications. These reagents are now offered in bundles with ICAM-1/CD54 Antibody (1A29) (see ordering information below).
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ICAM-1 Antibody (1A29) is a mouse monoclonal IgG1 kappa light chain antibody raised against a suspension of HEV-derived Ax cell line of rat origin, demonstrating reactivity with mouse, rat, and human species. ICAM-1 (1A29) monoclonal antibody works effectively in immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). ICAM-1, also known as CD54 or intercellular adhesion molecule-1, is a cell surface glycoprotein belonging to the immunoglobulin superfamily that plays a crucial role in mediating cell-cell adhesion during immune responses. ICAM-1 specifically interacts with integrins such as LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18) on leukocytes, facilitating their adhesion and transmigration across the endothelium. This interaction is vital for immune surveillance, inflammation, and the initiation of immune responses. ICAM-1 also interacts with proteins like fibrinogen and hyaluronan-binding protein 2, influencing cellular signaling pathways and vascular permeability. Understanding these protein-protein interactions helps advance research into inflammatory diseases, autoimmune disorders, and cancer metastasis, where altered ICAM-1 expression and function contribute to disease progression.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Contains Mercury: All HRP conjugates (including bundle forms) contain thiomersal, a mercury compound. Do not dispose in trash. Dispose as hazardous chemical waste according to local, state and federal regulations.
Download thiomersal SDS
ICAM-1/CD54 Antibody (1A29) References:
- ICAM-1 clustering on endothelial cells recruits VCAM-1. | van Buul, JD., et al. 2010. J Biomed Biotechnol. 2010: 120328. PMID: 20300427
- Regulation of ICAM-1 in cells of the monocyte/macrophage system in microgravity. | Paulsen, K., et al. 2015. Biomed Res Int. 2015: 538786. PMID: 25654110
- Involvement of ICAM-1 in impaired spermatogenesis after busulfan treatment in mice. | Cai, Y., et al. 2016. Andrologia. 48: 37-44. PMID: 25808259
- ICAM-1 suppresses tumor metastasis by inhibiting macrophage M2 polarization through blockade of efferocytosis. | Yang, M., et al. 2015. Cell Death Dis. 6: e1780. PMID: 26068788
- ICAM-1 Binding Rhinoviruses A89 and B14 Uncoat in Different Endosomal Compartments. | Conzemius, R., et al. 2016. J Virol. 90: 7934-42. PMID: 27334586
- Endothelial MAPKs Direct ICAM-1 Signaling to Divergent Inflammatory Functions. | Dragoni, S., et al. 2017. J Immunol. 198: 4074-4085. PMID: 28373581
- Endothelial transmigration hotspots limit vascular leakage through heterogeneous expression of ICAM-1. | Grönloh, MLB., et al. 2023. EMBO Rep. 24: e55483. PMID: 36382783
- Quercetin attenuates inflammation in rosacea by directly targeting p65 and ICAM-1. | Meng, X., et al. 2024. Life Sci. 347: 122675. PMID: 38688383
- Role of ICAM-1 in triple-negative breast cancer. | Zhang, Y., et al. 2024. Open Med (Wars). 19: 20240969. PMID: 38799250
- Circulating ICAM-1 in tuberculosis. | Lai, CK., et al. 1994. Am J Respir Crit Care Med. 150: 594-5. PMID: 7914136
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ICAM-1/CD54 Antibody (1A29) | sc-19584 | 200 µg/ml | $322.00 | |||
ICAM-1/CD54 Antibody (1A29): m-IgG Fc BP-HRP Bundle | sc-536616 | 200 µg Ab; 10 µg BP | $361.00 | |||
ICAM-1/CD54 Antibody (1A29): m-IgGκ BP-HRP Bundle | sc-533773 | 200 µg Ab; 40 µg BP | $361.00 | |||
ICAM-1/CD54 Antibody (1A29): m-IgG1 BP-HRP Bundle | sc-544710 | 200 µg Ab; 20 µg BP | $361.00 | |||
ICAM-1/CD54 Antibody (1A29) FITC | sc-19584 FITC | 200 µg/ml | $336.00 | |||
ICAM-1/CD54 Antibody (1A29) L | sc-19584 L | 200 µg/0.1 ml | $322.00 | |||
ICAM-1/CD54 Antibody (1A29) PE | sc-19584 PE | 200 µg/ml | $349.00 |