HTLV-2 p19 Antibody (11D1): sc-53892

HTLV-2 p19 Antibody (11D1) is a mouse monoclonal IgG1 kappa light chain antibody that detects HTLV-2 p19 protein of HTLV-2 origin by western blotting (WB) and immunofluorescence (IF). HTLV-2 p19 (11D1) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. HTLV-2 p19 protein plays a crucial role in the viral life cycle as a major core protein encoded by the gag gene, which is essential for the assembly and release of viral particles. Understanding p19 function is important because p19 not only aids in virus identification but also serves as a target for serological discrimination between HTLV-1 and HTLV-2, which is vital for accurate diagnosis and treatment of associated diseases. Human T-lymphotropic virus (HTLV) is a single-stranded RNA retrovirus linked to T cell leukemia and lymphoma in adults, as well as certain demyelinating diseases. While HTLV-1 is more widely studied due to its association with various diseases, HTLV-2 shares approximately 70% genomic homology with HTLV-1 and has been implicated in cases of myelopathy/tropical spastic paraparesis (HAM/TSP)-like neurological disorders. The differential antibody responsiveness to p19 gag protein can provide insights into the pathogenesis of these viruses and their clinical implications.

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HTLV-2 p19 Antibody (11D1) References:

1. Envelope is a major viral determinant of the distinct in vitro cellular transformation tropism of human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2.  |  Xie, L. and Green, PL. 2005. J Virol. 79: 14536-45. PMID: 16282453
2. Human T lymphotropic virus types I and II western blot seroindeterminate status and its association with exposure to prototype HTLV-I.  |  Yao, K., et al. 2006. J Infect Dis. 193: 427-37. PMID: 16388491
3. Human T-lymphotropic virus type 1 mitochondrion-localizing protein p13(II) is required for viral infectivity in vivo.  |  Hiraragi, H., et al. 2006. J Virol. 80: 3469-76. PMID: 16537614
4. Human T-cell leukemia virus (HTLV) in the United Kingdom.  |  Greaves, MF., et al. 1984. Int J Cancer. 33: 795-806. PMID: 6329969
5. Production and characterization of a monoclonal antibody directed against HTLV-1 p19: use in a specific capture enzyme immunoassay.  |  Ebersold, A., et al. 1993. Hybridoma. 12: 185-95. PMID: 7686136
6. [Molecular characterization of human T-cell lymphotrophic virus type II].  |  Takahashi, H. 1993. Hokkaido Igaku Zasshi. 68: 485-95. PMID: 8340046
7. Assessment of a new immunoassay for serological confirmation and discrimination of human T-cell lymphotropic virus infections.  |  Zrein, M., et al. 1998. Clin Diagn Lab Immunol. 5: 45-9. PMID: 9455879
8. Differential antibody responsiveness to p19 gag results in serological discrimination between human T lymphotropic virus type I and type II.  |  Lal, RB., et al. 1991. J Med Virol. 35: 232-6. PMID: 1687064
9. Substrates and inhibitors of human T-cell leukemia virus type I protease.  |  Ding, YS., et al. 1998. Biochemistry. 37: 17514-8. PMID: 9860866

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-HTLV-2 p19 Antibody (11D1) has 0 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

HTLV-2 p19 Antibody (11D1) Specifications

Alternate Product Name: HTLV-2 p19

Product Clone Name: 11D1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: HTLV-2 p19

Epitope Species: HTLV-2

Product Reactivity/Detection: HTLV-2 p19

Species Reactivity/Detection: HTLV-2

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IF

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for HTLV-2 p19 Antibody (11D1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin