HTLV-2 p19 Inhibitors
HTLV-2 p19 inhibitors represent a versatile group of chemicals focused on thwarting various stages of the retroviral life cycle to indirectly modulate the function and abundance of the p19 protein. A notable subset of these compounds, including Zidovudine, Lamivudine, and Tenofovir, belong to the NRTIs. These agents target the reverse transcription process, crucial for the synthesis and integration of viral DNA into the host genome. By attenuating this step, they indirectly impede the synthesis and presence of p19, a matrix protein pivotal for viral assembly.
Protease inhibitors like Nelfinavir, Darunavir, and Saquinavir form another important category. These molecules obstruct the cleavage of viral polyprotein precursors, curtailing the maturation of viral proteins and, consequently, their assembly. The inhibition of this maturation process indirectly impacts p19's functionality in the viral assembly. Other inhibitors such as Maraviroc, Fostemsavir, and Enfuvirtide act by blocking viral entry into host cells. By hindering this crucial initiation step, fewer viral particles undergo replication, indirectly influencing p19's role in assembly.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
3′-Azido-3′-deoxythymidine | 30516-87-1 | sc-203319 | 10 mg | $60.00 | 2 | |
Nucleoside reverse transcriptase inhibitor (NRTI) targeting the reverse transcription step of retroviruses like HTLV-2. Inhibition at this step can reduce the synthesis and integration of viral DNA, thus indirectly affecting p19's role in virus assembly. | ||||||
Lamivudine | 134678-17-4 | sc-221830 sc-221830A | 10 mg 50 mg | $102.00 $214.00 | 1 | |
Another NRTI that prevents reverse transcription. By reducing the synthesis of viral DNA, the role and presence of p19 can be indirectly diminished. | ||||||
Raltegravir | 518048-05-0 | sc-364600 sc-364600A sc-364600B sc-364600C sc-364600D | 5 mg 50 mg 100 mg 500 mg 1 g | $100.00 $821.00 $1229.00 $2861.00 $4085.00 | 21 | |
Integrase strand transfer inhibitor preventing the integration of viral DNA into the host genome. Reduced integration indirectly affects p19 as fewer viral particles will be produced. | ||||||
Nevirapine | 129618-40-2 | sc-208092 | 5 mg | $97.00 | 5 | |
Non-nucleoside reverse transcriptase inhibitor (NNRTI) that binds to and inhibits reverse transcriptase. Inhibiting this step impacts the synthesis of viral DNA, hence indirectly modulating p19. | ||||||
Efavirenz | 154598-52-4 | sc-207612 | 10 mg | $168.00 | 3 | |
Another NNRTI targeting reverse transcriptase. Like Nevirapine, Efavirenz can reduce the synthesis of viral DNA, thereby indirectly influencing p19. | ||||||
Nelfinavir | 159989-64-7 | sc-507314 | 10 mg | $168.00 | ||
Protease inhibitor that prevents the cleavage of viral polyprotein precursors. By inhibiting the maturation of viral proteins, Nelfinavir can indirectly impact p19's role in the viral assembly. | ||||||
Tenofovir | 147127-20-6 | sc-204335 sc-204335A | 10 mg 50 mg | $154.00 $633.00 | 11 | |
NRTI that affects the reverse transcription process of retroviruses. By impacting this step, the synthesis and integration of viral DNA can be hampered, indirectly affecting p19. | ||||||
Darunavir | 206361-99-1 | sc-218079 | 5 mg | $311.00 | 4 | |
Another protease inhibitor that hinders the cleavage of viral polyprotein precursors. Through the prevention of viral protein maturation, p19's function in assembly can be indirectly modulated. | ||||||