HSV-2 gE Antibody (E10b): sc-550892
- HSV-2 gE Antibody (E10b) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- raised against amino acids 24-405 of HSV-2 gE
- recommended for detection of HSV-2 gE by WB, IP and IF
- Anti-HSV-2 gE Antibody (E10b) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for HSV-2 gE Antibody (E10b). This work is in progress.
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SEE ALSO...
HSV-2 gE Antibody (E10b) is a mouse monoclonal IgG2a kappa light chain antibody that detects HSV-2 gE protein of HSV-2 origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-HSV-2 gE antibody (E10b) plays a critical role in understanding the mechanisms of viral entry and spread, as HSV-2 gE protein is a key component of the virus′s envelope glycoproteins, which facilitate membrane fusion. This process is essential for the herpes simplex virus′s ability to infect host cells and propagate within the host. HSV-2 gE protein, in conjunction with gI, forms a heterodimer that is instrumental in the cell-to-cell spread of the virus, effectively directing virions to cell junctions where they can interact with cellular receptors. This interaction is particularly important in neuronal cells, where the gE/gI complex is vital for the dissemination of the virus within the nervous system. Additionally, HSV-2 gE protein is involved in the sorting and transport of viral components to axon tips, which is crucial for the establishment of latency and reactivation of the virus. Using HSV-2 gE monoclonal antibody (E10b) in research can provide valuable insights into the viral lifecycle and potential therapeutic targets for controlling HSV-2 infections.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
HSV-2 gE Antibody (E10b) References:
- DNA sequence and genetic content of the HindIII l region in the short unique component of the herpes simplex virus type 2 genome: identification of the gene encoding glycoprotein G, and evolutionary comparisons. | McGeoch, DJ., et al. 1987. J Gen Virol. 68 (Pt 1): 19-38. PMID: 3027242
- Herpes Simplex Virus Cell Entry Mechanisms: An Update. | Madavaraju, K., et al. 2020. Front Cell Infect Microbiol. 10: 617578. PMID: 33537244
- The genome sequence of herpes simplex virus type 2. | Dolan, A., et al. 1998. J Virol. 72: 2010-21. PMID: 9499055
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HSV-2 gE Antibody (E10b) | sc-550892 | 200 µg/ml | $316.00 | |||
HSV-2 gE Antibody (E10b) AC | sc-550892 AC | 500 µg/ml, 25% agarose | $416.00 | |||
HSV-2 gE Antibody (E10b) HRP | sc-550892 HRP | 200 µg/ml | $316.00 | |||
HSV-2 gE Antibody (E10b) FITC | sc-550892 FITC | 200 µg/ml | $330.00 | |||
HSV-2 gE Antibody (E10b) PE | sc-550892 PE | 200 µg/ml | $343.00 | |||
HSV-2 gE Antibody (E10b) Alexa Fluor® 488 | sc-550892 AF488 | 200 µg/ml | $357.00 | |||
HSV-2 gE Antibody (E10b) Alexa Fluor® 546 | sc-550892 AF546 | 200 µg/ml | $357.00 | |||
HSV-2 gE Antibody (E10b) Alexa Fluor® 594 | sc-550892 AF594 | 200 µg/ml | $357.00 | |||
HSV-2 gE Antibody (E10b) Alexa Fluor® 647 | sc-550892 AF647 | 200 µg/ml | $357.00 | |||
HSV-2 gE Antibody (E10b) Alexa Fluor® 680 | sc-550892 AF680 | 200 µg/ml | $357.00 | |||
HSV-2 gE Antibody (E10b) Alexa Fluor® 790 | sc-550892 AF790 | 200 µg/ml | $357.00 |