HSV-1 ICP0 Antibody (11060): sc-53070
- HSV-1 ICP0 Antibody (11060) is a mouse monoclonal IgG2b κ HSV-1 ICP0 antibody, cited in 65 publications, provided at 200 µg/ml
- raised against recombinant Vmw110 protein, with epitope mapping within amino acids 20-105
- HSV-1 ICP0 Antibody (11060) is recommended for detection of HSV-1 ICP0 of viral origin by WB, IP and IF
- Anti-HSV-1 ICP0 Antibody (11060) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG2b BP-HRP are the preferred secondary detection reagents for HSV-1 ICP0 Antibody (11060) for WB applications. These reagents are now offered in bundles with HSV-1 ICP0 Antibody (11060) (see ordering information below).
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HSV-1 ICP0 Antibody (11060) is a mouse monoclonal IgG2b kappa light chain antibody that detects the HSV-1 ICP0 protein of viral origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). HSV-1 ICP0 (11060) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The infected cell protein 0 (ICP0) plays a crucial role as a general transactivator for all three classes of herpes simplex virus (HSV) genes, which is vital for the virus′s ability to replicate and establish infection. ICP0 is essential for overcoming the host′s antiviral defenses, as ICP0 disrupts the human BHC corepressor complex, thereby preventing the silencing of viral DNA. This function is particularly important because ICP0 enables viral reactivation from latency and switches to a lytic state, facilitating viral gene expression and replication. Additionally, ICP0 interacts with human centromere protein CENP-A, leading to CENP-A degradation, which further underscores ICP0′s role in manipulating host cellular machinery to favor viral propagation.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
HSV-1 ICP0 Antibody (11060) References:
- Degradation of nucleosome-associated centromeric histone H3-like protein CENP-A induced by herpes simplex virus type 1 protein ICP0. | Lomonte, P., et al. 2001. J Biol Chem. 276: 5829-35. PMID: 11053442
- Components of the REST/CoREST/histone deacetylase repressor complex are disrupted, modified, and translocated in HSV-1-infected cells. | Gu, H., et al. 2005. Proc Natl Acad Sci U S A. 102: 7571-6. PMID: 15897453
- ICP0 and the US3 protein kinase of herpes simplex virus 1 independently block histone deacetylation to enable gene expression. | Poon, AP., et al. 2006. Proc Natl Acad Sci U S A. 103: 9993-8. PMID: 16785443
- Herpes simplex virus type 1 latently infected neurons differentially express latency-associated and ICP0 transcripts. | Maillet, S., et al. 2006. J Virol. 80: 9310-21. PMID: 16940542
- Herpes simplex virus type 1 ICP0 localizes in the stromal layer of infected rabbit corneas and resides predominantly in the cytoplasm and/or perinuclear region of rabbit keratocytes. | Morishige, N., et al. 2006. J Gen Virol. 87: 2817-2825. PMID: 16963739
- ICP22 is required for wild-type composition and infectivity of herpes simplex virus type 1 virions. | Orlando, JS., et al. 2006. J Virol. 80: 9381-90. PMID: 16973544
- Characterization of the IE110 gene of herpes simplex virus type 1. | Perry, LJ., et al. 1986. J Gen Virol. 67 (Pt 11): 2365-80. PMID: 3023529
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HSV-1 ICP0 Antibody (11060) | sc-53070 | 200 µg/ml | $322.00 | |||
HSV-1 ICP0 Antibody (11060): m-IgG Fc BP-HRP Bundle | sc-525573 | 200 µg Ab; 10 µg BP | $361.00 | |||
HSV-1 ICP0 Antibody (11060): m-IgG2b BP-HRP Bundle | sc-549587 | 200 µg Ab; 10 µg BP | $361.00 | |||
HSV-1 ICP0 Antibody (11060) AC | sc-53070 AC | 500 µg/ml, 25% agarose | $424.00 | |||
HSV-1 ICP0 Antibody (11060) HRP | sc-53070 HRP | 200 µg/ml | $322.00 | |||
HSV-1 ICP0 Antibody (11060) FITC | sc-53070 FITC | 200 µg/ml | $336.00 | |||
HSV-1 ICP0 Antibody (11060) PE | sc-53070 PE | 200 µg/ml | $349.00 | |||
HSV-1 ICP0 Antibody (11060) Alexa Fluor® 488 | sc-53070 AF488 | 200 µg/ml | $364.00 | |||
HSV-1 ICP0 Antibody (11060) Alexa Fluor® 546 | sc-53070 AF546 | 200 µg/ml | $364.00 | |||
HSV-1 ICP0 Antibody (11060) Alexa Fluor® 594 | sc-53070 AF594 | 200 µg/ml | $364.00 | |||
HSV-1 ICP0 Antibody (11060) Alexa Fluor® 647 | sc-53070 AF647 | 200 µg/ml | $364.00 | |||
HSV-1 ICP0 Antibody (11060) Alexa Fluor® 680 | sc-53070 AF680 | 200 µg/ml | $364.00 | |||
HSV-1 ICP0 Antibody (11060) Alexa Fluor® 790 | sc-53070 AF790 | 200 µg/ml | $364.00 |