HSPBAP1 Antibody (B-1): sc-374290

HSPBAP1 Antibody (B-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects HSPBAP1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-HSPBAP1 antibody (B-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. HSPBAP1, also known as heat shock 27kDa associated protein 1 or PASS1, is a 488 amino acid cytoplasmic protein characterized by the presence of a JMJC (Jumonji C) domain, which is crucial for chromatin remodeling and cellular stress response. HSPBAP1 is widely expressed, with highest levels found in the ovary, thymus, and pancreas, indicating importance in various physiological processes. HSPBAP1 interacts with several key proteins involved in stress response pathways, which underscores potential role in mediating cellular adaptation to stress and implications in cancer biology, particularly in renal cell carcinoma, where defects or translocations in the HSPBAP1 gene have been implicated. The existence of three HSPBAP1 isoforms due to alternative splicing highlights the complexity of regulation and function, making HSPBAP1 (B-1) monoclonal antibody a valuable tool for researchers studying stress response mechanisms and their links to disease.

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HSPBAP1 Antibody (B-1) References:

1. Identification and characterization of a novel protein from Sertoli cells, PASS1, that associates with mammalian small stress protein hsp27.  |  Liu, C., et al. 2000. J Biol Chem. 275: 18724-31. PMID: 10751411
2. Molecular cloning and characterization of a novel human gene (HSPBAP1) from human fetal brain.  |  Jiang, M., et al. 2001. Cytogenet Cell Genet. 95: 48-51. PMID: 11978969
3. Disruption of a novel gene, DIRC3, and expression of DIRC3-HSPBAP1 fusion transcripts in a case of familial renal cell cancer and t(2;3)(q35;q21).  |  Bodmer, D., et al. 2003. Genes Chromosomes Cancer. 38: 107-16. PMID: 12939738
4. HSPBAP1 is found extensively in the anterior temporal neocortex of patients with intractable epilepsy.  |  Xi, ZQ., et al. 2007. Synapse. 61: 741-7. PMID: 17568411
5. Modulation of heat shock proteins during macrophage differentiation.  |  Fagone, P., et al. 2012. Inflamm Res. 61: 1131-9. PMID: 22706319
6. Androgen receptor-interacting protein HSPBAP1 facilitates growth of prostate cancer cells in androgen-deficient conditions.  |  Saeed, K., et al. 2015. Int J Cancer. 136: 2535-45. PMID: 25359680
7. Alcohol-Induced Behaviors Require a Subset of Drosophila JmjC-Domain Histone Demethylases in the Nervous System.  |  Pinzón, JH., et al. 2017. Alcohol Clin Exp Res. 41: 2015-2024. PMID: 28940624
8. MicroRNA-455-3p as a Potential Biomarker for Alzheimer's Disease: An Update.  |  Kumar, S. and Reddy, PH. 2018. Front Aging Neurosci. 10: 41. PMID: 29527164
9. The small members of the JMJD protein family: Enzymatic jewels or jinxes?  |  Oh, S., et al. 2019. Biochim Biophys Acta Rev Cancer. 1871: 406-418. PMID: 31034925
10. Use of human neuroblastoma SH-SY5Y cells to evaluate glyphosate-induced effects on oxidative stress, neuronal development and cell death signaling pathways.  |  Martínez, MA., et al. 2020. Environ Int. 135: 105414. PMID: 31874349
11. Fatigue and expression of heat-shock protein genes in plaque psoriasis.  |  Skoie, IM., et al. 2022. Clin Exp Dermatol. 47: 1068-1077. PMID: 34921435
12. Ferrous Ion Alleviates Lipid Deposition and Inflammatory Responses Caused by a High Cottonseed Meal Diet by Modulating Hepatic Iron Transport Homeostasis and Controlling Ferroptosis in Juvenile Ctenopharyngodon idellus.  |  Liu, H., et al. 2023. Antioxidants (Basel). 12: PMID: 38001821

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-HSPBAP1 Antibody (B-1) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-HSPBAP1 Antibody (B-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

HSPBAP1 Antibody (B-1) Specifications

Alternate Product Name: HSPBAP1

Product Clone Name: B-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: HSPBAP1

Epitope Species: human

Product Reactivity/Detection: HSPBAP1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for HSPBAP1 Antibody (B-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin