HSP90 alpha/beta Antibody (AC88): sc-59577
- HSP90 alpha/beta Antibody (AC88) is a mouse monoclonal IgG1, cited in 11 publications, provided at 100 µg/ml
- raised against HSP 90 of Achlya ambisexualis origin
- recommended for detection of HSP 90α and HSP 90β of mouse, rat, human, Achlya ambisexualis, C. elegans and bovine origin by WB, IP, IF and FCM
- See HSP90 alpha/beta (F-8): sc-13119 for HSP90 alpha/beta antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for HSP90 alpha/beta Antibody (AC88). This work is in progress.
HSP 90α/β Antibody (AC88) is a mouse monoclonal IgG1 antibody that detects HSP 90 across various species including mouse, rat, human, Achlya ambisexualis, C. elegans, and bovine, and is suitable for applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). HSP 90, a crucial molecular chaperone, plays a significant role in proper folding and stabilization of numerous client proteins, including steroid hormone receptors and kinases, which are vital for cellular signaling and stress responses. HSP 90′s function is underscored by involvement in protein maturation that regulates critical cellular processes, such as cell growth and survival, particularly under stress conditions. By facilitating correct protein conformation, HSP 90 ensures functional participation in signaling pathways, maintaining cellular homeostasis. Anti-HSP 90α/β antibody (AC88) serves as an essential tool for researchers studying heat shock response and intricate network of protein interactions pivotal for cellular resilience and adaptation.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
HSP90 alpha/beta Antibody (AC88) References:
- Heat shock genes - integrating cell survival and death. | Arya, R., et al. 2007. J Biosci. 32: 595-610. PMID: 17536179
- GCUNC45 is the first Hsp90 co-chaperone to show alpha/beta isoform specificity. | Chadli, A., et al. 2008. J Biol Chem. 283: 9509-12. PMID: 18285346
- Heat shock protein 90 is critical for regulation of phenotype and functional activity of human T lymphocytes and NK cells. | Bae, J., et al. 2013. J Immunol. 190: 1360-71. PMID: 23293352
- [Relationship between the expressions of glucocorticoid receptors α, β, γ, p and heat shock protein 90 mRNA in patients with primary immune thrombocytopenia resistant to the glucocorticoid]. | Ma, LL., et al. 2012. Zhonghua Xue Ye Xue Za Zhi. 33: 733-7. PMID: 23336227
- Roles of Extracellular HSPs as Biomarkers in Immune Surveillance and Immune Evasion. | Taha, EA., et al. 2019. Int J Mol Sci. 20: PMID: 31533245
- GP96 and SMP30 Protein Priming of Dendritic Cell Vaccination Induces a More Potent CTL Response against Hepatoma. | Huang, R., et al. 2022. J Healthc Eng. 2022: 2518847. PMID: 35070229
- Equine insulin dysregulation causes tissue specific alterations of proinflammatory cytokines and acute phase proteins in a NF-kB independent manner. | Jayathilake, WMNK., et al. 2022. Vet Immunol Immunopathol. 253: 110500. PMID: 36244309
- Characterization of cell line with dedifferentiated GIST-like features established from cecal GIST of familial GIST model mice. | Sano, D., et al. 2023. Pathol Int. 73: 181-187. PMID: 36825754
- A novel PET probe to selectively image heat shock protein 90α/β isoforms in the brain. | Sakai, T., et al. 2024. EJNMMI Radiopharm Chem. 9: 19. PMID: 38436869
- Molecular chaperones and the cytoskeleton. | Liang, P. and MacRae, TH. 1997. J Cell Sci. 110 (Pt 13): 1431-40. PMID: 9224761
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HSP90 alpha/beta Antibody (AC88) | sc-59577 | 100 µg/ml | $322.00 |