HSP 40-4 Antibody (A-9): sc-376544
- HSP 40-4 Antibody (A-9) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- raised against amino acids 308-360 mapping near the C-terminus of HSP 40 protein 4 of human origin
- recommended for detection of HSP 40-4 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for HSP 40-4 Antibody (A-9). This work is in progress.
HSP 40-4 Antibody (A-9) is a mouse monoclonal IgG2b antibody that detects HSP 40-4 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). HSP 40-4, also known as HDJ2, plays a crucial role in the cellular stress response by functioning as a co-chaperone that interacts with HSP 70 molecular chaperones, facilitating proper protein folding and mitochondrial protein import. HSP 40-4 is primarily located in the cytoplasm and mitochondria, where HSP 40-4 assists in maintaining cellular homeostasis under stress conditions. HSP 40-4′s presence in these locations is vital, as HSP 40-4 ensures that misfolded proteins are correctly refolded or targeted for degradation, thereby preventing the accumulation of toxic aggregates that can lead to cellular dysfunction. Additionally, HSP 40-4 contains a cysteine-rich zinc finger domain that may act as a redox sensor, allowing HSP 40-4 to respond dynamically to changes in the cellular redox environment. HSP 40-4′s interaction with the cellular redox enzyme thioredoxin highlights HSP 40-4′s importance in regulating protein folding in response to oxidative stress. Loss of HSP 40-4 has been associated with severe defects in spermatogenesis, indicating HSP 40-4′s essential role in reproductive health and androgen signaling pathways. Anti-HSP 40-4 antibody (A-9) is an invaluable tool for researchers studying the mechanisms of protein folding and the cellular response to stress.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HSP 40-4 Antibody (A-9) | sc-376544 | 200 µg/ml | $322.00 |