HSMNP1 Antibody (C-9): sc-514709
- HSMNP1 Antibody (C-9) is a mouse monoclonal IgG1 κ HSMNP1 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 135-156 within an internal region of HSMNP1 of human origin
- HSMNP1 Antibody (C-9) is recommended for detection of HSMNP1 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-HSMNP1 Antibody (C-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for HSMNP1 Antibody (C-9) for WB applications. These reagents are now offered in bundles with HSMNP1 Antibody (C-9) (see ordering information below).
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HSMNP1 Antibody (C-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects HSMNP1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). HSMNP1 (C-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. HSMNP1 protein, also known as dysbindin domain-containing protein 2 (DBNDD2) or casein kinase I binding protein (CK1BP), consists of 261 amino acids and is a member of the dysbindin family, which plays a crucial role in protein trafficking and lysosome biosynthesis. This function is particularly important as dysregulation of lysosomal function has been linked to various neurodegenerative diseases and psychiatric disorders, including schizophrenia and muscular dystrophy. HSMNP1 shares 86% identity with its human and rat counterparts and features three phosphorylation sites for casein kinase II and protein kinase C, a putative N-glycosylation site, and a PEST motif at the C-terminus, which is indicative of protein degradation signals. HSMNP1 is localized in the cytoplasm and specifically associates with vesicles during apoptosis, suggesting involvement in cellular stress responses. HSMNP1 may play a role in both normal and pathological myeloid development, and two isoforms arise from alternative splicing events, further diversifying functional capabilities.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
HSMNP1 Antibody (C-9) References:
- Dysbindin, a novel coiled-coil-containing protein that interacts with the dystrobrevins in muscle and brain. | Benson, MA., et al. 2001. J Biol Chem. 276: 24232-41. PMID: 11316798
- Dysbindin-1 is reduced in intrinsic, glutamatergic terminals of the hippocampal formation in schizophrenia. | Talbot, K., et al. 2004. J Clin Invest. 113: 1353-63. PMID: 15124027
- The human orthologue of a novel apoptosis response gene induced during rat myelomonocytic stem cell apoptosis maps to 20q13.12. | Lucas, T., et al. 2005. Stem Cells Dev. 14: 556-63. PMID: 16305340
- Dysbindin structural homologue CK1BP is an isoform-selective binding partner of human casein kinase-1. | Yin, H., et al. 2006. Biochemistry. 45: 5297-308. PMID: 16618118
- Characterization of NKIP: a novel, Na+/K+-ATPase interacting protein mediates neural differentiation and apoptosis. | Pratscher, B., et al. 2008. Exp Cell Res. 314: 463-77. PMID: 18096156
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HSMNP1 Antibody (C-9) | sc-514709 | 200 µg/ml | $322.00 | |||
HSMNP1 Antibody (C-9): m-IgG Fc BP-HRP Bundle | sc-531199 | 200 µg Ab; 10 µg BP | $361.00 | |||
HSMNP1 Antibody (C-9): m-IgGκ BP-HRP Bundle | sc-524820 | 200 µg Ab, 40 µg BP | $361.00 | |||
HSMNP1 Antibody (C-9): m-IgG1 BP-HRP Bundle | sc-544431 | 200 µg Ab; 20 µg BP | $361.00 | |||
HSMNP1 Antibody (C-9) AC | sc-514709 AC | 500 µg/ml, 25% agarose | $424.00 | |||
HSMNP1 Antibody (C-9) HRP | sc-514709 HRP | 200 µg/ml | $322.00 | |||
HSMNP1 Antibody (C-9) FITC | sc-514709 FITC | 200 µg/ml | $336.00 | |||
HSMNP1 Antibody (C-9) PE | sc-514709 PE | 200 µg/ml | $349.00 | |||
HSMNP1 Antibody (C-9) Alexa Fluor® 488 | sc-514709 AF488 | 200 µg/ml | $364.00 | |||
HSMNP1 Antibody (C-9) Alexa Fluor® 546 | sc-514709 AF546 | 200 µg/ml | $364.00 | |||
HSMNP1 Antibody (C-9) Alexa Fluor® 594 | sc-514709 AF594 | 200 µg/ml | $364.00 | |||
HSMNP1 Antibody (C-9) Alexa Fluor® 647 | sc-514709 AF647 | 200 µg/ml | $364.00 | |||
HSMNP1 Antibody (C-9) Alexa Fluor® 680 | sc-514709 AF680 | 200 µg/ml | $364.00 | |||
HSMNP1 Antibody (C-9) Alexa Fluor® 790 | sc-514709 AF790 | 200 µg/ml | $364.00 | |||
HSMNP1 (C-9) Neutralizing Peptide | sc-514709 P | 100 µg/0.5 ml | $69.00 |